Results 51 to 60 of about 204,987 (288)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Therapeutic Ultrasound-Enhanced Immune Checkpoint Inhibitor Therapy

Frontiers in Physics, 2021
Immune checkpoint inhibitors (ICIs) are designed to reinvigorate antitumor immune responses by interrupting inhibitory signaling pathways and promote the immune-mediated elimination of malignant cells.
Jinyun Yuan, Dezhuang Ye, Si Chen, Hong Chen, Hong Chen   +4 more
doaj   +1 more source

Negative Immune Checkpoint Inhibitors

Pharmaceutics
Checkpoint inhibitors are a modern therapeutic approach for treating various types of cancer, metabolic diseases, and chronic infections. The main goal of this therapy is to specifically unlock the immune system, allowing it to recognize and eliminate cancer cells or pathogens, primarily through the activation of T lymphocytes.
Magda Drewniak-Świtalska, Paulina Fortuna, Małgorzata Krzystek-Korpacka   +2 more
openaire   +3 more sources

Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC). [PDF]

, 2018
The landscape of head and neck squamous cell carcinoma (HNSCC) has been changing rapidly due to growing proportion of HPV-related disease and development of new therapeutic agents.
Jung, Kyungsuk, Kang, Hyunseok, Mehra, Ranee   +2 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies [PDF]

, 2017
We would like to thank all patients whose samples were used in this study. We are also thankful to the Northern Ireland Biobank and Grampian Biorepository for providing us with tissue blocks and patient data; and Dr HG Coleman (Queen’s University Belfast)
A Gonçalves, Brendan Pang, Claire McGready, CM McCourt, D Barras, DT Le, E Vilar, Graeme I Murray, J Guinney, J Siehl, Jacqueline A James, K Masago, KJ Lastwika, M Arnold, M Lek, M Toyota, MA Alvi, Manuel Salto-Tellez, Marc-Aurel Fuchs, Mark Lawler, Maurice B Loughrey, MF Kane, ML Iacono, Muhammad A Alvi, NJ Llosa, Perry Maxwell, Philip Dunne, Richard H Wilson, Richard Turkington, RS Herbst, S Kakar, SC Casey, Stephen McQuaid, T Anthony, The Genomes Project C, U Nitsche, V Gopalan, Victoria Bingham, Wendy Moore, Y Xiao   +39 more
core   +2 more sources

Immunotherapy, Inflammation and Colorectal Cancer. [PDF]

, 2020
Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality rates among cancer-related deaths in the United States.
Karin, Michael, Lichtenstern, Charles Robert, Ngu, Rachael Katie, Shalapour, Shabnam   +3 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling

Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors have traditionally been understood to exert their effects primarily within the tumor microenvironment, particularly targeting CD8 + T cells. However, recent studies have highlighted a pivotal role of tumor-draining
Jinzhu Zhang, Jian Ma, Yaru Niu, Jialiang Liu, Zhexue Wang, Jinyuan Guo, Yongsheng Meng, Ruifang Sun, Zhen Zhang, Haiyi Liu, Juan Xu, Likun Zan, Xu Guan, Xishan Wang   +13 more
doaj   +1 more source

Immune Checkpoint Inhibitor Induced Hepatitis Injury:

Translation, 2023
Please view the PDF to see the formatted meeting abstract.  
Danae Hamouda
doaj   +1 more source