Results 111 to 120 of about 1,810,595 (288)

PowerPoint Slides for: Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

, 2017
Background: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor ...
Uppal N.N. (3629581), Wanchoo R. (3629575), Deray G. (3629590), Karam S. (3629578), Launay-Vacher V. (3629569), Barta V.S. (3629587), Devoe C. (3629572), Jhaveri K.D. (3629584), on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (3629566)   +8 more
core   +1 more source

Immune Checkpoint Inhibitors for Unresectable Hepatocellular Carcinoma

, 2020
Despite the advances in screening protocols and treatment options, hepatocellular carcinoma (HCC) is still considered to be the most lethal malignancy in patients with liver cirrhosis.
Samer Saadi, Christian Cotsoglou, Mohamed Elnaggar, Mohamed A. Abd El Aziz Abd El Maksoud, Mohamed A. Abd El Aziz, Antonio Facciorusso, Tarek Nayfeh, Rodolfo Sacco   +7 more
core   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among U.S. Veterans

Arthritis Care &Research, Accepted Article.
Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Pharmacology of Immune Checkpoint Inhibitors

Immune checkpoint inhibitors are a class of drugs that act on immune checkpoints (the three major ones being CTLA4, PD-1, and PD-L1) and are novel treatment options for cancer.
Panigrahi, Debi
core  

Supplementary Material for: Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review

, 2017
Background: Cancer immunotherapy, such as anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death 1 (PD-1), has revolutionized the treatment of malignancies by engaging the patient's own immune system against the tumor ...
Uppal N.N. (3629581), Wanchoo R. (3629575), Deray G. (3629590), Karam S. (3629578), Launay-Vacher V. (3629569), Barta V.S. (3629587), Devoe C. (3629572), Jhaveri K.D. (3629584), on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (3629566)   +8 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Hepatotoxicity induced by immune checkpoint inhibitors [PDF]

Immune checkpoint inhibitors (ICIs) are an effective immunotherapeutic approach for cancers affecting the lung, skin, kidney, mammary gland, or certain hematologic malignancies.
Alexescu, Teodora Gabriela, Fabian, Ovidiu Vasile, George Ciulei, Perne, Mirela Georgiana, Pocol, Tinca Codruta, Muresan, Flaviu, Madalina Daiana Bancos, Ciulei, George, Bancos, Madalina Daiana, Madalina Bancos, Orasan, Olga Hilda, Tinca Pocol, Flaviu Muresan, Mirela Georgiana Perne, Angela Cozma, Mirela Perne, Leach, Nicoleta Valentina, Ovidiu Vasile Fabian, Ovidiu Fabian, Ciumarnean, Lorena, Cozma, Angela, Teodora Gabriela Alexescu, Milaciu, Mircea Vasile, Lorena Ciumarnean, Nicoleta Valentina Leach, Olga Hilda Orasan, Mircea Vasile Milaciu, Tinca Codruta Pocol, Nicoleta Leach, Mircea Milaciu, Teodora Alexescu, Olga Orasan   +31 more
core   +1 more source