Results 111 to 120 of about 199,032 (289)
Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome
Arthritis Care &Research, EarlyView.Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino +9 more
wiley +1 more source
The discovery of immune checkpoints (ICs) has pushed cancer treatment into the next era. As an emerging immune checkpoint, the TIGIT/CD155 axis inhibits the cytotoxicity of T and NK cells through multiple pathways.
Elkord, Eyad +2 more
core +1 more source
Advanced Functional Materials, EarlyView.A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam +8 more
wiley +1 more source
Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine
Advanced Materials Interfaces, EarlyView.Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee +3 more
wiley +1 more source
Predictive biomarkers for tumor immune checkpoint blockade
, 2018 Mengting Tong,1,2,* Jing Wang,2,* Wenting He,1 Yanling Wang,2 Hongming Pan,2 Da Li,2 Hongliang Zhang1 1Second Department of Medical Oncology, The Fourth Affiliated Hospital of Xinjiang Medical University, Saybagh District, Urumqi, Xinjiang 830000, People&
Pan H +6 more
core
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Immune checkpoint inhibitors in urothelial cancer: recent updates and future outlook
, 2018 Dharmesh Gopalakrishnan,1 Vadim S Koshkin,2 Moshe C Ornstein,2 Athanasios Papatsoris,3 Petros Grivas2,4 1Department of Hospital Medicine, Cleveland Clinic, Cleveland, OH, USA; 2Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland ...
Gopalakrishnan D +4 more
core
Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma
, 2020 With the understanding of the complex interaction between the tumour microenvironment and immunotherapy, there is increasing interest in the role of immune regulators in the treatment of head and neck squamous cell carcinoma (HNSCC).
Junwen Huang +7 more
core +1 more source
Advanced Science, EarlyView.This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui +14 more
wiley +1 more source
Immune checkpoint inhibitors: Unravelling atherosclerotic cardiovascular risk.
1. IntroductionThe development of immune checkpoint inhibitors (ICI) has transformed the landscape of cancer treatment in the past decade with these agents becoming the standard of care in the treatment of many malignancies [1].
Manisty, Charlotte +5 more
core +1 more source