Results 121 to 130 of about 177,775 (151)

Cardiotoxicity of Immune Checkpoint Inhibitors

Current Treatment Options in Cardiovascular Medicine, 2019
Immunotherapies, particularly immune checkpoint inhibitors (ICI), are revolutionary cancer therapies being increasingly applied to a broader range of cancers. Our understanding of the mechanism, epidemiology, diagnosis, and treatment of cardiotoxicity related to immunotherapies remains limited.
Lili, Zhang, Maeve, Jones-O'Connor, Magid, Awadalla, Daniel A, Zlotoff, Paaladinesh, Thavendiranathan, John D, Groarke, Alexandra-Chloe, Villani, Alexander R, Lyon, Tomas G, Neilan   +8 more
openaire   +2 more sources

Immune checkpoint inhibitor myocarditis

Current Opinion in Cardiology, 2019
The purpose of this study is to summarize and highlight the recent literature regarding immune checkpoint inhibitor myocarditis.The use of immune checkpoint inhibitors, a promising form of immunotherapy, is rapidly increasing in oncology. These drugs have been recently found to cause a fulminant myocarditis associated with a high-case fatality rate ...
Jayant, Raikhelkar, Nir, Uriel
openaire   +2 more sources

Radiotherapy, immunity, and immune checkpoint inhibitors

The Lancet Oncology
Radiotherapy exerts immunostimulatory and immunosuppressive effects, both locally, within the irradiated tumour microenvironment, and systemically, outside the radiation field. Inspired by preclinical data that showed synergy between radiotherapy and immune checkpoint inhibitors, multiple clinical trials were initiated with the hypothesis that combined
Connor, Lynch, Sean P, Pitroda, Ralph R, Weichselbaum   +2 more
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Immune Checkpoint Inhibitors in Gliomas

Current Oncology Reports, 2017
Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable. Novel therapies to improve outcomes are needed and immune checkpoint inhibitors hold significant promise.A limited body of preclinical evidence suggests that checkpoint inhibitors may be effective ...
Aaron C, Tan, Amy B, Heimberger, Mustafa, Khasraw   +2 more
openaire   +2 more sources

Immune Checkpoint Inhibitors in Cholangiocarcinoma

Immunotherapy, 2023
Cholangiocarcinoma is an epithelial malignancy originating in the biliary tracts and frequently recurs even with surgical resection. Unresectable disease has a 5-year overall survival of less than 10%. Given this poor prognosis, additional therapies are urgently needed. Chemotherapy has been the mainstay of treatment for many years.
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Melanoma and Immune Checkpoint Inhibitors

Current Oncology Reports, 2018
Prognosis of patients with advanced melanoma is dismal with a median overall survival of about 8 months and 5-year overall survival from a diagnosis of metastatic disease of roughly 10%. However, immune checkpoint inhibitors have brought indispensable benefits to melanoma patients.
Masutaka, Furue, Takamichi, Ito, Naoko, Wada, Maiko, Wada, Takafumi, Kadono, Hiroshi, Uchi   +5 more
openaire   +2 more sources

Immune Checkpoint Inhibitor–Induced Lipodystrophy

JAMA Dermatology
This case series describes lipodystrophy, a rare adverse event associated with immune checkpoint inhibitor therapy.
Riganti J., Torre A. C., Sollena P., Koumaki D., Freites-Martinez A., Delyon J., Communie A., Starace M., Rapparini L., Lallas A., Mavroudis D., Suzanne D., Mazzuoccolo L. D., Bobos M., Sibaud V., Apalla Z.   +15 more
openaire   +3 more sources

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Annual Review of Pathology: Mechanisms of Disease, 2021
Edgar Engleman, Robert Yuan
exaly  

Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies

Nature Reviews Drug Discovery, 2021
Ryan Sullivan, Jeffrey Weber, Sullivan Ryan J   +2 more
exaly  

Immune-related adverse events of immune checkpoint inhibitors: a review

Frontiers in Immunology, 2023
Lan Bai, Lian Li, Tong Rongsheng
exaly