Results 171 to 180 of about 268,746 (338)

P118 THE RISK OF DIARRHEA AND COLITIS IN PATIENTS WITH ADVANCED MELANOMA UNDERGOING IMMUNE-CHECKPOINT INHIBITOR THERAPY [PDF]

, 2018
Parul Tandon, Samuel Bourassa‐Blanchette, Kirles Bishay, Simon Parlow, Scott A. Laurie, Jeffrey D. McCurdy   +5 more
openalex   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

The Effect of Non-Overlapping Somatic Mutations in BRAF, NRAS, NF1, or CKIT on the Incidence and Outcome of Brain Metastases during Immune Checkpoint Inhibitor Therapy of Metastatic Melanoma [PDF]

Wolfram E. Samlowski
openalex   +1 more source

Data from A DNA Hypomethylating Drug Alters the Tumor Microenvironment and Improves the Effectiveness of Immune Checkpoint Inhibitors in a Mouse Model of Pancreatic Cancer

, 2023
Tamas A. Gonda, Jarwei Fang, Martha Salas, Catherine Do, Emily Hsu, Anna Zhukovskaya, Ariel Siegel, Ryota Takahashi, Zoila A. Lopez‐Bujanda, Charles G. Drake, Gulam A. Manji, Timothy C. Wang, Kenneth P. Olive, Benjamin Tycko   +13 more
openalex   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, EarlyView.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

A Case of St-Segment Elevation Myocardial Infarction and Thrombocytopenia Induced by Immune Checkpoint Inhibitor Sintilimab

, 2023
Lijuan Guo, Yuan Chang
openalex   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

The pattern of tumor progression on first-line immune checkpoint inhibitor-based systemic therapy for Chinese advanced hepatocellular carcinoma –CLEAP 004 study [PDF]

Chao-Xu Yang, Yangxun Pan, Feng Ye, Xiao‐Dong Zhu, Jun Xue, Xi Li, Zhen-Gang Yuan, Lan Zhang, Li Xu, Yongjun Chen, Nan-Ya Wang, Hui‐Chuan Sun, Xiufeng Liu, China Liver Cancer Study Group Young Investigators (CLEAP)   +13 more
openalex   +1 more source