Results 91 to 100 of about 3,908,577 (301)

Selective escape from CD8+ T-Cell responses represents a major driving force of Human Immunodeficiency Virus Type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [PDF]

, 2005
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen remain unclear.
Rockstroh, J.K., O'Sullivan, K.M., Maier, E.L., Reyor, L., DeSouza, I., Altfeld, M., Moore, C., Lahaie, M.P., Johnston, M.N., Feeney, M.E., Rosenberg, E.S., Draenert, R., Kaufmann, D.E., Kalife, E.T., Brander, C., Eldridge, R.L., Walker, B.D., Tanzi, G., Jessen, H., Allen, T.M., Mallal, S.A., Geer, S.C.   +21 more
core  

Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness [PDF]

, 2014
Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
core   +1 more source

JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA.

Cancer Research, 2022
The RNA N6-methyladenosine (m6A) writer methyltransferase-like 3 (METTL3) is upregulated in many types of cancer and promotes cancer progression by increasing expression of several oncogenes. Therefore, a better understanding of the mechanisms regulating
Z. Ni, P. Sun, Jin Zheng, Mingqing Wu, Congcong Yang, Mao-Sheng Cheng, Mingwei Yin, Chengying Cui, Guang-Xi Wang, Lin Yuan, Qian Gao, Yang Li   +11 more
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The relationship between autophagy and PD-L1 and their role in antitumor therapy

Frontiers in Immunology, 2023
Immune checkpoint blockade therapy is an important advance in cancer treatment, and the representative drugs (PD-1/PD-L1 antibodies) have greatly improved clinical outcomes in various human cancers.
Yu Cui, Jinfeng Shi, Youbin Cui, Zhanpeng Zhu, Wei Zhu   +4 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Dynamics of Immune Escape during HIV/SIV Infection [PDF]

, 2008
Several studies have shown that cytotoxic T lymphocytes (CTLs) play an important role in controlling HIV/SIV infection. Notably, the observation of escape mutants suggests a selective pressure induced by the CTL response. However, it remains difficult to
Rob J De Boer, Althaus, Christian L., De Boer, Rob J., Christian L Althaus, Christian L. Althaus, Rob J. De Boer, Pascual, Mercedes   +6 more
core   +3 more sources

Immune escape of colorectal tumors via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids. [PDF]

, 2023
Control of tumor development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumors from destruction by the immune system is currently unclear.
Karamitopoulou, Eva, Julia Koerner, Merk, Verena M., Brunner, Thomas, Merk, Verena M, Asma Ahmed, Karamitopoulou, Evanthia, Gollob, Kenneth J, Reinhold, Cindy, Farin, Henner F, Bode, Konstantin, Israel Toja da Silva, Eileen Breunig, Breunig, Eileen, Thomas Brunner, Truong San Phan, Plazzo, Anna Pia, Gollob, Kenneth J., Henner F. Farin, Toja da Silva, Israel, Verena M. Merk, Feodora Kostadinova, Anna Pia Plazzo, Kostadinova, Feodora, Mario Noti, San Phan, Truong, Constantin Menche, Nahle, Fatima, Cindy Reinhold, Menche, Constantin, Lea Dietrich, Urwyler, Corinne, Noti, Mario, Phan, Truong San, Eva Karamitopoulou, da Silva, Israel Toja, Regula Stuber, Fatima Nahle, Ahmed, Asma, Dietrich, Lea, Koerner, Julia, Corinne Urwyler, Stuber, Regula, Konstantin Bode, Farin, Henner F., Kenneth J. Gollob, Pia Plazzo, Anna   +46 more
core   +2 more sources

Inhibition of CK2/ING4 Pathway Facilitates Non‐Small Cell Lung Cancer Immunotherapy

Advanced Science, 2023
Immune cells can protect against tumor progression by killing cancer cells, while aberrant expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer cells facilitates tumor immune escape and inhibits anti‐tumor immunotherapy.
Qian Gou, Huiqing Chen, Mingjun Chen, Juanjuan Shi, Jianhua Jin, Qian Liu, Yongzhong Hou   +6 more
doaj   +1 more source

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient: a source of immune escape variants

medRxiv, 2021
The recent emergence of SARS-CoV-2 variants showing increased transmissibility and immune escape is a matter of global concern. Their origin remains unclear, but intra-host virus evolution during persistent infections could be a contributing factor. Here,
Sebastian Weigang, Jonas Fuchs, G. Zimmer, D. Schnepf, Lisa Kern, J. Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, J. Kemming, M. Hofmann, R. Thimme, C. Neumann-Haefelin, Svenja Ulferts, R. Grosse, D. Hornuss, Y. Tanriver, S. Rieg, D. Wagner, D. Huzly, M. Schwemmle, M. Panning, G. Kochs   +22 more
semanticscholar   +1 more source