Results 191 to 200 of about 3,908,577 (301)

Epstein-Barr virus reprograms immune escape in nasopharyngeal carcinoma. [PDF]

Virulence
Liu Q, Tong Y, Sun T, He L, Xu X, You K.
europepmc   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Immune escape in endometriosis: mechanisms, reprogramming strategies, and precision interventions. [PDF]

Reprod Biol Endocrinol
Chen H, Zhang M, Fei W, Zhang Q, Peng Y, Zhu L, Ding S, Zhang X, Chen Z, Zhao M.   +9 more
europepmc   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

CRACD loss drives hypoxia-induced immune escape in gastric cancer. [PDF]

Nat Commun
Seo Y, Jang J, Ko KP, Zou G, Kim SM, Huang Y, Zhang S, Zhang J, Jun S, Chu W, Venkatesan V, Dhakshinamoorthy S, Kim H, Park JI.   +13 more
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Hypoxia-driven tumor immune escape: mechanisms and therapeutic opportunities. [PDF]

Front Immunol
Qin H, Yang S, He J, Zhao M, Zhao L, Wang J, Jiang X, Chen X, Xu X.   +8 more
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

TNFR1 expression on cancer cells mediates immune escape and an immunosuppressive microenvironment. [PDF]

J Exp Med
Bolaños E, Cañas-Zabala L, Olivera I, Ruiz Guillamón D, Vercher E, Gomis G, de Andrea CE, Alexandru R, Azpilikueta A, Soria N, Salinas D, Molero-Glez P, Luri-Rey C, Arrieta-Aranzueque S, Manzanal A, Garcia-Dominguez M, Alignani D, Ségui B, Molina A, Teijeira Á, Berraondo P, Melero I.   +21 more
europepmc   +1 more source