Results 91 to 100 of about 1,940,572 (373)

YTH domain family protein 3 accelerates non-small cell lung cancer immune evasion through targeting CD8+ T lymphocytes

open access: yesCell Death Discovery
Immune evasion is one of the critical hallmarks of malignant tumors, especially non-small cell lung cancer (NSCLC). Emerging findings have illustrated the roles of N6-methyladenosine (m6A) on NSCLC immune evasion.
Yisheng Luo   +12 more
doaj   +1 more source

RAILS: A Robust Adversarial Immune-inspired Learning System [PDF]

open access: yesarXiv, 2020
Adversarial attacks against deep neural networks are continuously evolving. Without effective defenses, they can lead to catastrophic failure. The long-standing and arguably most powerful natural defense system is the mammalian immune system, which has successfully defended against attacks by novel pathogens for millions of years.
arxiv  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

Complex pattern of immune evasion in MSI colorectal cancer

open access: yesOncoImmunology, 2018
Mismatch repair (MMR)-deficient cancers accumulate multiple insertion/deletion mutations at coding microsatellites (cMS), which give rise to frameshift peptide neoantigens.
Mine Ozcan   +3 more
doaj   +1 more source

Beware of Mycoplasma Anti-immunoglobulin Strategies

open access: yesmBio, 2021
Mycoplasmas are small, genome-reduced bacteria. They are obligate parasites that can be found in a wide range of host species, including the majority of livestock animals and humans. Colonization of the host can result in a wide spectrum of outcomes.
Yonathan Arfi   +3 more
doaj   +1 more source

Non-Markovian and Collective Search Strategies [PDF]

open access: yesarXiv, 2023
Agents searching for a target can improve their efficiency by memorizing where they have already been searching or by cooperating with other searchers and using strategies that benefit from collective effects. This chapter reviews such concepts: non-Markovian and collective search strategies. We start with the first passage properties of continuous non-
arxiv  

High levels of cyclic-di-GMP in plant-associated Pseudomonas correlate with evasion of plant immunity [PDF]

open access: yes, 2016
The plant innate immune system employs plasma membrane-localized receptors that specifically perceive pathogen/microbe-associated molecular patterns (PAMPs/MAMPs).
Aragon   +68 more
core   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

Immune Evasion of SARS-CoV-2 Omicron Subvariants

open access: yesVaccines, 2022
Since the SARS-CoV-2 Omicron variant (B.1.1.529) was declared a variant of concern (VOC) by the WHO on 24 November 2021, it has caused another global surge of cases.
Hanzhong Ke   +2 more
semanticscholar   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

open access: yesMolecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou   +13 more
wiley   +1 more source

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