Results 101 to 110 of about 121,779 (302)

Increased Expression of Fas Ligand in Human Tuberculosis and Leprosy Lesions: a Potential Novel Mechanism of Immune Evasion in Mycobacterial Infection [PDF]

, 2001
Tehmina Mustafa, Gunnar Bjune, Roland Jonsson, Rogelio Hernández‐Pando, Rune Nilsen   +4 more
openalex   +1 more source

Antibody‐Programmable Bimetallic Nanozymes for Transcriptional Blockade Therapy in HER2/ER‐Positive Breast Cancer

Advanced Functional Materials, EarlyView.
Zr‐Fe MOF@Ribociclib@Herceptin (ZFRH) efficiently targets/kills Human Epidermal Growth Factor Receptor 2/Estrogen Receptor‐positive (HER2/ER+) breast cancer cells. It combats tumors by: 1) Elevating ROS, altering redox balance; 2) Inhibiting transcription; 3) Inducing pyroptosis.
Hongkun Miao, Tong Ye, Mingjiang Liu, Jingchao Gao, Lian Tan, Qian Dong, Qingbo Lv, Qianqian Ye, Yu Wang   +8 more
wiley   +1 more source

Penicillin‐binding proteins in Streptococcus agalactiae: a novel mechanism for evasion of immune clearance [PDF]

, 2002
Amanda L. Jones, Rachel H. V. Needham, Anne Clancy, Katherine M. Knoll, Craig E. Rubens   +4 more
openalex   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

An Immune Evasion Mechanism for Spirochetal Persistence in Lyme Borreliosis [PDF]

, 2002
Fang Ting Liang, Mary B. Jacobs, Lisa C. Bowers, Mario T. Philipp   +3 more
openalex   +1 more source

Precision Photothermal Therapy at Mild Temperature: NIR‐II Imaging‐Guided, H2O2‐Responsive Stealth Nanobomb

Advanced Healthcare Materials, EarlyView.
The new generation nanobomb, termed the stealth nanobomb, is fabricated through self‐assembly using a polymeric carbon monoxide carrier (PLGA(CO)), small molecule near‐infrared‐active agents (2TT‐OC46B), and phospholipid polyethylene glycol (DSPE‐mPEG2000). The stealth nanobomb can circulate in the bloodstream and specifically target pancreatic cancer,
Gongcheng Ma, Qihang Ding, Yue Wang, Zhiwei Zhang, Yuding Zhang, Hui Shi, Lintao Cai, Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim   +10 more
wiley   +1 more source

A co-culture model to study modulators of tumor immune evasion through scalable arrayed CRISPR-interference screens

Frontiers in Immunology
Cancer cells effectively evade immune surveillance, not only through the well-known PD-1/PD-L1 pathway but also via alternative mechanisms that impair patient response to immune checkpoint inhibitors.
Ramiro Martinez, Ramiro Martinez, Ramiro Martinez, Chiara Finocchiaro, Louis Delhaye, Louis Delhaye, Louis Delhaye, Louis Delhaye, Fien Gysens, Fien Gysens, Fien Gysens, Jasper Anckaert, Jasper Anckaert, Jasper Anckaert, Wim Trypsteen, Wim Trypsteen, Wim Trypsteen, Maarten Versteven, Eva Lion, Sandra Van Lint, Sandra Van Lint, Sandra Van Lint, Karim Vermaelen, Karim Vermaelen, Karim Vermaelen, Eric James de Bony, Eric James de Bony, Eric James de Bony, Pieter Mestdagh, Pieter Mestdagh, Pieter Mestdagh   +30 more
doaj   +1 more source

Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do‐Wan Kim, Dajeong Kim, Choong‐Min Ryu   +9 more
wiley   +1 more source

Delivery of Islatravir via High Drug‐Load, Long‐acting Microarray Patches for the Prevention or Treatment of Human Immunodeficiency Virus

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Islatravir‐loaded dissolving microarray patches (MAPs) provide a minimally invasive, long‐acting solution for HIV‐1 prevention and treatment. In rats, sustained islatravir delivery lasts up to three months, while in minipigs, efficacious plasma levels are detected for six days.
Qonita Kurnia Anjani, Ashley R. Johnson, Akmal H. Sabri, Ryan Lutz, Steven Tignor, Jeanine Ballard, Nathan Rudd, Li Zhao, Lalitkumar K. Vora, Stephanie E. Barrett, Angela Wagner, Ryan F. Donnelly   +11 more
wiley   +1 more source