Results 241 to 250 of about 241,317 (354)

The mechanism of action and therapeutic potential of tumor-associated macrophages in tumor immune evasion [PDF]

Kehua Wang, Xu Zhang, Aiqin Li, Xia Qiao, Yanan Xu   +4 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

IRF4 Promotes Immune Evasion and Shapes the Tumor Microenvironment in Follicular Lymphoma. [PDF]

Blood Cancer Discov
Dasari S, Wenzl K, Nelson GM, Contreras Guzman E, Wang Z, Chartier L, Yang ZZ, Villasboas JC, Olson J, Mukherjee P, Bhardwaj V, Tang X, Negaard BJ, Zakrzewski JL, King RL, Huet S, Tesson B, Maurer MJ, Morschhauser F, Nowakowski GS, Adelman KL, Singh H, Pasqualucci L, Shlomchik M, Novak AJ, Ansell SM, Mondello P.   +26 more
europepmc   +1 more source

Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L

, 2013
Frédéric Sorgeloos, Babal K. Jha, Robert H. Silverman, Thomas Michiels   +3 more
openalex   +2 more sources

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

PD-1 Expression Promotes Immune Evasion in B-ALL. [PDF]

Hematol Rep
Casado-García A, García-Aguilera G, Pozo J, Oak N, Barrena S, Ruiz-Corzo B, Lalchandani J, Chamorro-Vera A, Castillo-Robleda A, Soriano B, Alemán-Arteaga S, Sánchez EG, Martínez-Cano J, López-Álvarez de Neyra A, Somoza-Cotillas P, Blanco O, Riesco S, Prieto-Matos P, García Criado FJ, García Cenador MB, Cobaleda C, Vicente-Dueñas C, Nichols KE, Orfao A, Ramírez-Orellana M, Sánchez-García I.   +25 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

SKP2 at the crossroads of proliferation and immune evasion: a new target in the tumor microenvironment. [PDF]

Precis Clin Med
Vlachostergios PJ, Boussios S.
europepmc   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Host-Microbe Interactions: Understanding the Mechanism of Autophagy in Viral Replication and Immune Evasion. [PDF]

Vet Sci
Fu Z, Li X, Abd El-Aty AM, Yagan R, Ju X, Yong Y.   +5 more
europepmc   +1 more source