Results 71 to 80 of about 1,940,572 (373)

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Molecular Cancer, 2021
Background An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. Circular RNAs (circRNAs) have been implicated in cancer progression.
Zhenchuan Liu, Tingting Wang, Y. She, Kaiqin Wu, Shaorui Gu, Lei Li, C. Dong, Chang Chen, Yongxin Zhou   +8 more
semanticscholar   +1 more source

Do Tumor Mechanical Stresses Promote Cancer Immune Escape?

Cells, 2022
Immune evasion—a well-established cancer hallmark—is a major barrier to immunotherapy efficacy. While the molecular mechanisms and biological consequences underpinning immune evasion are largely known, the role of tissue mechanical stresses in these ...
Killian Onwudiwe, Julian Najera, Saeed Siri, Meenal Datta   +3 more
doaj   +1 more source

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

Nature Communications, 2022
Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined.
P. Nguyen, M. Wasser, C. Tan, C. Lim, H. Lai, Justine Jia Wen Seow, R. Dasgupta, C. Phua, Siming Ma, Ji-cheng Yang, Sheena Suthen, W. Tam, T. Lim, Joe Poh-Sheng Yeong, W. Leow, Y. Pang, G. Soon, T. Loh, W. Wan, C. Chan, P. Cheow, H. Toh, A. Kow, Y. Dan, J. Kam, Shridhar Iyer, K. Madhavan, A. Chung, G. Bonney, B. Goh, Nai-jie Fu, V. C. Yu, Weiwei Zhai, S. Albani, P. Chow, Valerie Chew   +35 more
semanticscholar   +1 more source

KRAS drives immune evasion in a genetic model of pancreatic cancer

Nature Communications, 2021
Immune evasion is a hallmark of KRAS-driven cancers, but the underlying causes remain unresolved. Here, we use a mouse model of pancreatic ductal adenocarcinoma to inactivate KRAS by CRISPR-mediated genome editing.
I. Ischenko, S. D'Amico, M. Rao, Jinyu Li, M. Hayman, S. Powers, O. Petrenko, N. Reich   +7 more
semanticscholar   +1 more source

How human papillomavirus replication and immune evasion strategies take advantage of the host DNA damage repair machinery [PDF]

, 2017
The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation.
Bordignon, Valentina, Cavallo, Ilaria, Di Domenico, Enea Gino, D’Agosto, Giovanna, Ensoli, Fabrizio, Mariani, Luciano, Pimpinelli, Fulvia, Pontone, Martina, Trento, Elisabetta   +8 more
core   +2 more sources

Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Nature Communications, 2021
Little is known about the transcriptomic plasticity and adaptive mechanisms of circulating tumor cells (CTCs) during hematogeneous dissemination. Here we interrogate the transcriptome of 113 single CTCs from 4 different vascular sites, including hepatic ...
Yunfan Sun, Liang Wu, Shiping Liu, Miaomiao Jiang, Bo Hu, Kaiqian Zhou, Wei Guo, Yang Xu, Y. Zhong, Xiaorui Zhou, Zefan Zhang, Geng Liu, Sheng Liu, Yinghong Shi, Yuan Ji, M. Du, Nan-Nan Li, Guibo Li, Zhikun Zhao, Xiao-yun Huang, Liqin Xu, Qichao Yu, D. Peng, S. Qiu, Hui-Chuan Sun, M. Dean, Xiang-dong Wang, W. Chung, A. Dennison, Jian Zhou, Yong Hou, Jia Fan, Xinrong Yang   +32 more
semanticscholar   +1 more source

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells [PDF]

, 2014
Immune evasion genes help human cytomegalovirus (HCMV) establish lifelong persistence. Without immune pressure, laboratory-adapted HCMV strains have undergone genetic alterations.
Aicheler, Andrew J. Davison, Arnon, Benedict, Bentz, Billadeau, Borivoj Vojtesek, Brown, Butler, Cerboni, Chapman, Dargan, Davis, Eddie C.Y. Wang, Evans, Fielding, Gavin S. Wilkie, Gavin W.G. Wilkinson, Gross, Humphries, Jürgen Haas, Kelly L. Miners, Kim, Le, Mace, Marco A. Purbhoo, Marcus Heinzmann, Melanie Moore, Michael P. Weekes, Morris, Orange, Paul J. Lehner, Penfold, Peter Tomasec, Prod’homme, Prod’homme, Prod’homme, Rak, Rebecca J. Aicheler, Richard J. Stanton, Riedl, Robin Antrobus, Ryu, Seo, Smith, Stanton, Stanton, Stanton, Stephen Man, Striebinger, Susanne M. Bailer, Takenawa, Tani, Taylor, Tomasec, Tomasec, Umashankar, Virginie Prod’homme, Wang, Weekes, Wilkinson   +60 more
core   +3 more sources

Genetically Modified T-Cell-Based Adoptive Immunotherapy in Hematological Malignancies

Journal of Immunology Research, 2017
A significant proportion of hematological malignancies remain limited in treatment options. Immune system modulation serves as a promising therapeutic approach to eliminate malignant cells.
Baixin Ye, Creed M. Stary, Qingping Gao, Qiongyu Wang, Zhi Zeng, Zhihong Jian, Lijuan Gu, Xiaoxing Xiong   +7 more
doaj   +1 more source

Unveiling the stealthy tactics: mycoplasma’s immune evasion strategies

Frontiers in Cellular and Infection Microbiology, 2023
Mycoplasmas, the smallest known self-replicating organisms, possess a simple structure, lack a cell wall, and have limited metabolic pathways. They are responsible for causing acute or chronic infections in humans and animals, with a significant number ...
Jingyun Wang, Keying Liang, Li Chen, Xiaoling Su, Daoyong Liao, Jianwei Yu, Jianwei Yu, Jun He   +7 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source