Results 21 to 30 of about 1,542,000 (267)

Gross Total Resection Promotes Subsequent Recovery and Further Enhancement of Impaired Natural Killer Cell Activity in Glioblastoma Patients

Brain Sciences, 2022
Glioblastoma is the most common primary malignant brain tumor, and median survival is relatively short despite aggressive standard treatment. Natural killer (NK) cell dysfunction is strongly associated with tumor recurrence and metastasis but is unclear ...
Cheng-Chi Lee, Jeng-Fu You, Yu-Chi Wang, Shao-Wei Lan, Kuo-Chen Wei, Ko-Ting Chen, Yin-Cheng Huang, Tai-Wei Erich Wu, Abel Po-Hao Huang   +8 more
doaj   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Effect of Different Doses of Vitamin D on the Intestinal Flora of Babies with Eczema: An Experimental Study

Life, 2022
Infantile eczema is a common allergic disease caused by a variety of factors, which is often accompanied by immune dysfunction and dysbiosis of the intestinal flora.
Youping Liu, Meng Yang, Zhiling Ran, Junxia Wang, Wujie Ma, Qiaoni Sheng   +5 more
doaj   +1 more source

Macrophages in homeostatic immune function [PDF]

Frontiers in Physiology, 2014
Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance.
Jonathan eJantsch, Katrina Jean Binger, Dominik N N Muller, Jens M Titze, Jens M Titze   +4 more
openaire   +6 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Mitochondrial damage drives T-cell immunometabolic paralysis after major surgery

EMBO Molecular Medicine
Cytotoxic T cell (CTL) dysfunction is a hallmark of immune paralysis after major surgery, increasing susceptibility to severe nosocomial infections and contributing to mortality in critically ill patients. The mechanisms remain poorly understood.
Simon Hirschberger, Martin B Müller, Hannah Mascolo, Melissa Seitz, Stefan Nibler, David Effinger, Kun Lu, Joscha Büch, Martin Bender, Tobias Kammerer, Sven Peterß, Karin Kleigrewe, Miriam Abele, Teresa Barth, Olga Kushnir, Axel Imhof, Steffen Dietzel, Bernd Wegener, Ralf Sowa, Frank Vogel, Peter Lamm, Roland Tomasi, Kristian Unger, Markus Sperandio, Erich Kilger, Simone Kreth, Max Hübner   +26 more
doaj   +1 more source

Optineurin Functions for Optimal Immunity [PDF]

Frontiers in Immunology, 2018
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor. Since then, OPTN has been identified as a ubiquitin-binding protein involved in many signaling pathways and cellular processes, and mutations in the OPTN gene have been associated with glaucoma,
Karolina Slowicka, Karolina Slowicka, Geert van Loo, Geert van Loo   +3 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ICAMs in Immunity, Intercellular Adhesion and Communication

Cells
Interactions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs).
Claudia Guerra-Espinosa, María Jiménez-Fernández, Francisco Sánchez-Madrid, Juan M. Serrador   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source