Results 171 to 180 of about 443 (202)

Bifidobacteria-mediated immune system imprinting early in life [PDF]

Cell, 2021
Immune-microbe interactions early in life influence the risk of allergies, asthma, and other inflammatory diseases. Breastfeeding guides healthier immune-microbe relationships by providing nutrients to specialized microbes that in turn benefit the host's immune system.
Lakshmikanth Tadepally, Mark Underwood, Axel Olin   +2 more
exaly   +4 more sources

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Immune imprinting in utero

Science, 2021
Mild maternal infection causes tissue-specific epigenetic imprinting in ...
Mohammed, Amir, Melody Y, Zeng
openaire   +2 more sources

Prenatal stress, fetal imprinting and immunity

Brain, Behavior, and Immunity, 2008
A comprehensive number of epidemiological and animal studies suggests that prenatal and early life events are important determinants for disorders later in life. Among them, prenatal stress (i.e. stress experienced by the pregnant mother with impact on the fetal ontogeny) has programming effects on the hypothalamic-pituitary-adrenocortical axis, brain ...
Merlot, Elodie, Couret, David, Otten, Wilfred   +2 more
openaire   +5 more sources

A mother's touch: microbial guardians of early immune imprinting

Trends in Immunology
The evolution of the fetal immune system within the womb is a delicate balancing act: it is trained to not reject maternal antigens, while equipping itself with 'learned' immunity to survive and thrive in the outside world. In this opinion article, we propose that a deliberate maternal touch via immune and nutritional influences, orchestrated, in part,
Julia A Brown, Melody Zeng
exaly   +4 more sources

Deceptive imprinting and immune refocusing in vaccine design

Vaccine, 2008
A large number of the world's most widespread and problematic pathogens evade host immune responses by inducing strain-specific immunity to immunodominant epitopes with high mutation rates capable of altering antigenic profiles. The immune system appears to be decoyed into reacting to these immunodominant epitopes that offer little cross protection ...
Gregory J, Tobin, Jessie D, Trujillo, Ruth V, Bushnell, George, Lin, A Ray, Chaudhuri, Jinxue, Long, Jose, Barrera, Lindomar, Pena, Marvin J, Grubman, Peter L, Nara   +9 more
openaire   +2 more sources

A window of opportunity for immune imprinting

Science Translational Medicine, 2019
Host immune responses during a short weaning period determine susceptibility to inflammatory pathologies later in life.
openaire   +1 more source

Deceptive imprinting in the immune response against HIV-1

Immunology Today, 1994
The clonal profile of anti-HIV-1 antibodies is established at the time of infection as part of a vigorous immune response against HIV-1, and remains stable during the infection process. This bias towards antibodies specific for the initially infecting clonal virus population, termed imprinting, is inappropriate for attempts of the infected host to ...
H, Köhler, S, Müller, P L, Nara
openaire   +2 more sources

Immunoendocrinology: Faulty hormonal imprinting in the immune system

Acta Microbiologica et Immunologica Hungarica, 2014
Hormonal imprinting is an epigenetic process which is taking place perinatally at the first encounter between the developing hormone receptors and their target hormones. The hormonal imprinting influences the binding capacity of receptors, the hormone synthesis of the cells, and other hormonally regulated functions, as sexual behavior, aggressivity ...
openaire   +3 more sources

Imprinting, immunodominance, and other impediments to generating broad influenza immunity

Immunological Reviews, 2020
AbstractNatural influenza virus infections and seasonal vaccinations often do not confer broadly neutralizing immunity across diverse influenza strains. In addition, the virus is capable of rapid antigenic drift in order to evade pre‐existing immunity.
Matthew Knight, Siriruk Changrob, Lei Li, Patrick C. Wilson   +3 more
openaire   +2 more sources

Immune protection against SARS-CoV-2 re-reinfection and immune imprinting

2022
Abstract We investigated epidemiological evidence for immune imprinting by comparing incidence of re-reinfection in the national cohort of individuals with a documented Omicron (BA.1/BA.2) reinfection after a pre-Omicron primary infection (designated as the reinfection cohort), to incidence of reinfection in the national cohort of ...
Hiam Chemaitelly, Houssein H. Ayoub, Patrick Tang, Mohammad R. Hasan, Peter Coyle, Hadi M. Yassine, Hebah A. Al-Khatib, Maria K Smatti, Zaina Al-Kanaani, Einas Al-Kuwari, Andrew Jeremijenko, Anvar Hassan Kaleeckal, Ali Nizar Latif, Riyazuddin Mohammad Shaik, Hanan F. Abdul-Rahim, Gheyath K. Nasrallah, Mohamed Ghaith Al-Kuwari, Adeel A. Butt, Hamad Eid Al-Romaihi, Mohamed H. Al-Thani, Abdullatif Al-Khal, Roberto Bertollini, Laith J. Abu-Raddad   +22 more
openaire   +1 more source