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Gut immune microenvironment and autoimmunity
International Immunopharmacology, 2023A variety of immune cells or tissues are present in the gut to form the gut immune microenvironment by interacting with gut microbiota, and to maintain the gut immune homeostasis. Accumulating evidence indicated that gut microbiota dysbiosis might break the homeostasis of the gut immune microenvironment, which was associated with many health problems ...
Qiaolin Wang +3 more
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Tumor Microenvironment and Immune Escape
Surgical Oncology Clinics of North America, 2007This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
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The peritumor microenvironment: physics and immunity
Trends in Cancer, 2023Cancer initiation and progression drastically alter the microenvironment at the interface between healthy and malignant tissue. This site, termed the peritumor, bears unique physical and immune attributes that together further promote tumor progression through interconnected mechanical signaling and immune activity.
Sue Zhang +5 more
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Tumor Microenvironment and the Immune Response
Surgical Oncology Clinics of North America, 2007Without clinical information, accurate follow-up, high-quality sample collection, and preservation, scientific conclusions are only based on theoretical assumptions that are unlikely to lead to clinical breakthroughs. In this article we discuss our understanding of the relationship between cancer cells and the host immune response.
S. Selleri +4 more
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The Tumor Microenvironment Reprograms Immune Cells
Cellular Reprogramming, 2022Tumor tissue comprises a highly complex network of diverse cell types. The tumor microenvironment (TME) can be mainly subdivided into cancer cells and stromal cell compartments, the latter include different types of immune cells, fibroblasts, endothelial cells, and pericytes.
Handi Cao +3 more
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The immune microenvironment in cutaneous leishmaniasis
Journal of the European Academy of Dermatology and Venereology, 2014AbstractBackgroundCutaneous leishmaniasis is an infection that has spread to non‐endemic regions, stimulating recent interest for the enhanced understanding of this disease. Downregulation of the CD1a receptor on Langerhans cells has been described in various cutaneous infections.ObjectiveIn this study, the immune response across different Ridley ...
M N, Jabbour +7 more
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The immune microenvironment in gastric adenocarcinoma
Nature Reviews Gastroenterology & Hepatology, 2022Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma (GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal, endothelial and immune cells. In this article, we review the role of the immune microenvironment in the progression of chronic inflammation to GAC, primarily the immune ...
Yana, Zavros, Juanita L, Merchant
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[Hepatocellular carcinoma immune microenvironment].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2022The tumor immune microenvironment (TIME) plays crucial roles in the growth, progression, and therapeutic response of hepatocellular carcinoma(HCC) which is a prototypical inflammation-associated cancer. The efficacy of immunotherapy largely depends on the TIME.
T G, Miao, Y M, Nan
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Adaptive Immunity and the Tumor Microenvironment
2020The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
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Multiple Myeloma and the Immune Microenvironment
Current Cancer Drug Targets, 2017One of the great advances in the field of cancer therapy in recent years is the emergence of immune therapies. Immune therapies, especially immune checkpoint inhibitors, have shown promising results in pre-clinical models and clinical trials of solid tumors, such as melanoma, breast cancer and lung cancer ...
Yawara, Kawano +3 more
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