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Adaptive Immunity and the Tumor Microenvironment
2020The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
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The immune microenvironment in cutaneous leishmaniasis
Journal of the European Academy of Dermatology and Venereology, 2014AbstractBackgroundCutaneous leishmaniasis is an infection that has spread to non‐endemic regions, stimulating recent interest for the enhanced understanding of this disease. Downregulation of the CD1a receptor on Langerhans cells has been described in various cutaneous infections.ObjectiveIn this study, the immune response across different Ridley ...
M N, Jabbour +7 more
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The Macroimportance of the Pulmonary Immune Microenvironment
American Journal of Respiratory Cell and Molecular Biology, 1999The incidence of asthma is at near-epidemic levels among the peoples of industrialized countries ( see review by Cookson and colleagues [1]). Hypotheses for this proliferation have included increases in air pollution, early exposure to trigger antigens (e.g., dust mites, cockroaches), genetic factors, and differences in the amount of time spent inside ...
N A, Lee, J J, Lee
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Immune Suppression in the Tumor Microenvironment
Journal of Immunotherapy, 2006The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski +2 more
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Gut microenvironment and immune function
Current Opinion in Clinical Nutrition and Metabolic Care, 1999Overreaction of the acute phase response is responsible for the two major complications to surgery, sepsis and thrombosis, but also most likely for the leading sequela to surgery, adhesion formation. The gastrointestinal tract, especially the colon, is a major player in the acute phase response and responsible for important immune functions with ...
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Cytokines and Immune Response in the Tumor Microenvironment
Journal of Immunotherapy, 2001SUMMARY: Over the last few decades a wealth of evidence has been gathered on the potential role that the immune system (IS) can play in the fight against cancer. Together with cell surface adhesion molecules, cytokines (CKs) mediate the activities of IS cells.
MOCELLIN, SIMONE, WANG E, MARINCOLA FM
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Structural Correlates of Immune Microenvironment
1973In this introductory note I should just like to make a few general remarks on the importance of lymphatic cell morphology, the necessity for the theoretical approaches to the study of immune response, and the existence of many connections among apparently different tissues, to sketch the principal components of the microenvironment of lymphatic tissue ...
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The immune microenvironment of colorectal cancer
Nature Reviews CancerColorectal cancer (CRC) progression depends on the close interaction of tumour cells and the tumour microenvironment (TME). Although the TME contributes to poor therapy responses and immune evasion, immune cells within the TME can be therapeutically leveraged, as exemplified by immune checkpoint blockade (ICB).
Kilian B. Kennel, Florian R. Greten
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The rewired immune microenvironment in leukemia
Nature ImmunologyLeukemias are a class of human cancers that originate from hematopoietic progenitors and are characterized by extensive remodeling of the immune microenvironment. Leukemic cells, on transformation, acquire the ability to evade immune recognition but, despite undergoing genetic and epigenetic changes, retain their characteristic immature immune ...
Zoe Ciantra +2 more
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Role of the microenvironment in immune responses to transplantation
Springer Seminars in Immunopathology, 2003Through the constant interplay of cellular and extracellular components, the microenvironment of tissues directs immune responses. In solid organ transplantation, one factor that significantly alters the microenvironment of tissues is reperfusion injury, which occurs to a certain extent in essentially all cadaver organs.
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