Results 271 to 280 of about 1,580,087 (314)
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Multiple Myeloma and the Immune Microenvironment
Current Cancer Drug Targets, 2017One of the great advances in the field of cancer therapy in recent years is the emergence of immune therapies. Immune therapies, especially immune checkpoint inhibitors, have shown promising results in pre-clinical models and clinical trials of solid tumors, such as melanoma, breast cancer and lung cancer ...
Yawara, Kawano +3 more
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Adaptive Immunity and the Tumor Microenvironment
2020The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
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The immune microenvironment in gastric adenocarcinoma
Nature Reviews Gastroenterology & Hepatology, 2022Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma (GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal, endothelial and immune cells. In this article, we review the role of the immune microenvironment in the progression of chronic inflammation to GAC, primarily the immune ...
Yana, Zavros, Juanita L, Merchant
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The immune microenvironment in cutaneous leishmaniasis
Journal of the European Academy of Dermatology and Venereology, 2014AbstractBackgroundCutaneous leishmaniasis is an infection that has spread to non‐endemic regions, stimulating recent interest for the enhanced understanding of this disease. Downregulation of the CD1a receptor on Langerhans cells has been described in various cutaneous infections.ObjectiveIn this study, the immune response across different Ridley ...
M N, Jabbour +7 more
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Tumor Microenvironment and Immune Escape
Surgical Oncology Clinics of North America, 2007This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
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Immune checkpoints in the tumor microenvironment
Seminars in Cancer Biology, 2020Interactions between immune checkpoints (ICs) and their ligands negatively regulate T cell activation pathways involved in physiological immune responses against specific antigens. ICs and their ligands are frequently upregulated in the tumor microenvironment (TME) of various malignancies, and they represent significant barriers for induction of ...
Salman M, Toor +3 more
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The Immune Microenvironment of Breast Cancer Progression [PDF]
Cancers, 2019 Inflammation is now recognized as a hallmark of cancer. Genetic changes in the cancer cell are accepted as the match that lights the fire, whilst inflammation is seen as the fuel that feeds the fire. Once inside the tumour, the immune cells secrete cytokines that kick-start angiogenesis to ferry in much-needed oxygen and nutrients that encourage the ...
Kara Britt
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The tumour immune microenvironment in oesophageal cancer
British Journal of Cancer, 2021Oesophageal cancer (OC) is an inflammation-associated malignancy linked to gastro-oesophageal reflux disease, obesity and tobacco use. Knowledge of the microenvironment of oesophageal tumours is relevant to our understanding of the development of OC and its biology, and has major implications for understanding the response to standard therapies and ...
Maria Davern +6 more
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The Macroimportance of the Pulmonary Immune Microenvironment
American Journal of Respiratory Cell and Molecular Biology, 1999The incidence of asthma is at near-epidemic levels among the peoples of industrialized countries ( see review by Cookson and colleagues [1]). Hypotheses for this proliferation have included increases in air pollution, early exposure to trigger antigens (e.g., dust mites, cockroaches), genetic factors, and differences in the amount of time spent inside ...
N A, Lee, J J, Lee
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The immune microenvironment of colorectal cancer
Nature Reviews CancerColorectal cancer (CRC) progression depends on the close interaction of tumour cells and the tumour microenvironment (TME). Although the TME contributes to poor therapy responses and immune evasion, immune cells within the TME can be therapeutically leveraged, as exemplified by immune checkpoint blockade (ICB).
Kilian B. Kennel, Florian R. Greten
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