Results 261 to 270 of about 2,850,822 (303)

Tumor Microenvironment and Immune Escape

Surgical Oncology Clinics of North America, 2007
This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
Soldano, Ferrone, Theresa L, Whiteside
openaire   +2 more sources

Multiple Myeloma and the Immune Microenvironment

Current Cancer Drug Targets, 2017
One of the great advances in the field of cancer therapy in recent years is the emergence of immune therapies. Immune therapies, especially immune checkpoint inhibitors, have shown promising results in pre-clinical models and clinical trials of solid tumors, such as melanoma, breast cancer and lung cancer ...
Yawara, Kawano, Aldo M, Roccaro, Irene M, Ghobrial, Jamil, Azzi   +3 more
openaire   +2 more sources

Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo‐Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment

Advances in Materials, 2023
Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated immunosuppressive microenvironment diminish the immune response rate and the therapeutic effect. Surface modification of these drugs with target ligands can promote their cellular
Yunkun Li, Yahui Wu, Zaixiang Fang, Yuxin Zhang, H. Ding, Long Ren, Lu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo   +9 more
semanticscholar   +1 more source

Adaptive Immunity and the Tumor Microenvironment

2020
The adaptive immune response is a 500-million-year-old (the "Big Bang" of Immunology) collective set of rearranged and/or selected receptors capable of recognizing soluble and cell surface molecules or shape (B cells, antibody), endogenous and extracellular peptides presented by Major Histocompatibility (MHC) molecules including Class I and Class II ...
, Han, , Lotze
openaire   +2 more sources

Demystifying the cGAS-STING pathway: precision regulation in the tumor immune microenvironment

Molecular Cancer
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway serves as an immune sentinel for cytosolic DNA, recognizing double-stranded DNA (dsDNA) derived from abnormally localized nuclear DNA or mitochondrial DNA (mtDNA),
Qingyang Wang, Yang Yu, Zhuang Jing, Ruijuan Liu, Changgang Sun   +4 more
semanticscholar   +1 more source

The immune microenvironment in cutaneous leishmaniasis

Journal of the European Academy of Dermatology and Venereology, 2014
AbstractBackgroundCutaneous leishmaniasis is an infection that has spread to non‐endemic regions, stimulating recent interest for the enhanced understanding of this disease. Downregulation of the CD1a receptor on Langerhans cells has been described in various cutaneous infections.ObjectiveIn this study, the immune response across different Ridley ...
M N, Jabbour, G, Issa, K, Charafeddine, Y, Simaan, M, Karam, H, Khalifeh, R, Habib, I, Khalifeh   +7 more
openaire   +2 more sources

The Macroimportance of the Pulmonary Immune Microenvironment

American Journal of Respiratory Cell and Molecular Biology, 1999
The incidence of asthma is at near-epidemic levels among the peoples of industrialized countries ( see review by Cookson and colleagues [1]). Hypotheses for this proliferation have included increases in air pollution, early exposure to trigger antigens (e.g., dust mites, cockroaches), genetic factors, and differences in the amount of time spent inside ...
N A, Lee, J J, Lee
openaire   +2 more sources

The tumor microenvironment’s role in the response to immune checkpoint blockade

Nature Cancer
Beyond cancer cells, the tumor microenvironment (TME) includes cells of the innate and adaptive immune systems but also non-immune cells, such as fibroblasts and endothelial cells.
Konstantinos Aliazis, A. Christofides, Rushil Shah, Y. Y. Yeo, Sizun Jiang, Alain Charest, V. Boussiotis   +6 more
semanticscholar   +1 more source

Versatile conductive hydrogel orchestrating neuro-immune microenvironment for rapid diabetic wound healing through peripheral nerve regeneration.

Biomaterials
Diabetic wound (DW), notorious for prolonged healing processes due to the unregulated immune response, neuropathy, and persistent infection, poses a significant challenge to clinical management.
Siwei Bi, Changyuan He, Yannan Zhou, Ruiqi Liu, Chong Chen, Xueshan Zhao, Li Zhang, Ying Cen, Jun Gu, Bin Yan   +9 more
semanticscholar   +1 more source

Immune Suppression in the Tumor Microenvironment

Journal of Immunotherapy, 2006
The identification of tumor-expressed antigens that can be recognized by specific T lymphocytes has made it possible both to study the properties of T cells participating in anti-tumor immune responses in patients and also to develop antigen-specific immunotherapies as a treatment modality.
Thomas F, Gajewski, Yuru, Meng, Helena, Harlin   +2 more
openaire   +2 more sources