Results 211 to 220 of about 44,461 (250)

Pre-eclampsia, antiretroviral therapy, and immune reconstitution

The Lancet, 2002
Antiretrovirals are standard treatment for HIV-1-positive women during pregnancy in the UK, but little is known about maternal or fetal safety. In our cohort study of 214 pregnant women with HIV-1 infection, those who received no antiretroviral therapy had a rate of pre-eclampsia significantly lower (none of 61) than those on triple antiretroviral ...
R C, Wimalasundera, N, Larbalestier, J H, Smith, A, de Ruiter, S A, McG Thom, A D, Hughes, N, Poulter, L, Regan, G P, Taylor   +8 more
openaire   +2 more sources

The immune reconstitution inflammatory syndrome and antiretroviral therapy

British Journal of Hospital Medicine, 2010
Although generally mild, severe immune reconstitution inflammatory syndrome may complicate antiretroviral therapy, and it may be difficult to differentiate from treatment failure or toxicity. This article looks at diagnostic and therapeutic challenges of severe infectious manifestations of immune reconstitution inflammatory syndrome.
Lorent, N., Conesa-Botella, A., Colebunders, R.   +2 more
openaire   +3 more sources

Immune Reconstitution Inflammatory Syndrome Associated with Biologic Therapy

Current Allergy and Asthma Reports, 2014
The use of biologics in the treatment of autoimmune disease, cancer, and other immune conditions has revolutionized medical care in these areas. However, there are drawbacks to the use of these medications including increased susceptibility to opportunistic infections.
Malika, Gupta, Kashif, Jafri, Rebecca, Sharim, Susanna, Silverman, Sayantani B, Sindher, Anupama, Shahane, Mildred, Kwan   +6 more
openaire   +2 more sources

B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies

Nature Reviews Neurology, 2021
Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of the development and physiological functions of B cells and the main mechanisms through which B cells are thought to contribute to CNS autoimmunity.
Maria T. Cencioni, Miriam Mattoscio, Roberta Magliozzi, Amit Bar-Or, Paolo A. Muraro   +4 more
openaire   +3 more sources

Immune reconstitution therapies: concepts for durable remission in multiple sclerosis

Nature Reviews Neurology, 2019
New so-called immune reconstitution therapies (IRTs) have the potential to induce long-term or even permanent drug-free remission in people with multiple sclerosis (MS). These therapies deplete components of the immune system with the aim of allowing the immune system to renew itself.
Jan D. Lünemann, Tobias Ruck, Paolo A. Muraro, Amit Bar-Or, Heinz Wiendl   +4 more
openaire   +2 more sources

Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome and Unmasking of Tuberculosis by Antiretroviral Therapy

Clinics in Chest Medicine, 2009
The tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent early complication of antiretroviral therapy (ART), used to treat HIV-1 infection, especially in countries where TB is prevalent. TB-IRIS is characterized by an exaggerated inflammatory response toward the antigens of Mycobacterium tuberculosis that results ...
, Robert Wilkinson, Graeme Meintjes
exaly   +3 more sources

Immune reconstitution inflammatory syndrome versus non-immune reconstitution inflammatory syndrome lymphoma in HIV patients on antiretroviral therapy

International Journal of STD & AIDS, 2016
Little is known about differences between immune reconstitution inflammatory syndrome (IRIS) and non-IRIS lymphoma in HIV patients on antiretroviral therapy (ART). The aim of this study was to describe the characteristics of IRIS and non-IRIS lymphoma in Korean HIV-positive patients on ART compared with lymphoma in those off ART.
Pyoeng Gyun, Choe, Jinyong, Park, Wan Beom, Park, Tae Min, Kim, Kyoung-Ho, Song, Ji Hwan, Bang, Eu Suk, Kim, Sang Won, Park, Hong Bin, Kim, Nam Joong, Kim, Myoung-Don, Oh, Kang Won, Choe   +11 more
openaire   +2 more sources

THE IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME: A CAUSE OF DEATH IN PERSONS ON ANTIRETROVIRAL THERAPY?

Acta Clinica Belgica, 2013
The availability of antiretroviral therapy (ART) has significantly improved the quality of life of persons with HIV infection. However, new problems have arisen as a consequence of this treatment. An immune reconstitution inflammatory syndrome (IRIS) in which patients experience a paradoxical worsening of their clinical condition may occur during ...
Huis in 't Veld, D., Lukande, R., Lammens, M., Conesa-Botella, A., Vlieghe, E., Van Marck, Eric, Pauwels, Patrick, Colebunders, R.   +7 more
openaire   +3 more sources

Immunological consequences of “immune reconstitution therapy” in multiple sclerosis: A systematic review

Autoimmunity Reviews, 2020
Immune reconstitution therapy (IRT) is an emerging concept for the treatment of multiple sclerosis (MS) that is given intermittently and can induce long-term remission of MS that is sustained in treatment-free periods. A systematic literature review was performed to identify and summarize current knowledge regarding the short- and long-term ...
Johann, Sellner, Paulus S, Rommer
openaire   +2 more sources

[Antiretroviral therapy and immune reconstitution].

Journal de la Societe de biologie, 2000
The course of the HIV infection has been dramatically modified since the introduction of highly active antiretroviral therapy (HAART) combining inhibitors of the HIV-1 reverse transcriptase and protease. Despite some controversies about the extent to which the immune system can normalize, it is generally admitted nowadays that a numerical and ...
G, Carcelain, T S, Li, M, Renaud, C, Blanc, R, Tubiana, V, Calvez, J, Leibowitch, P, Debré, H, Agut, C, Katlama, B, Autran   +10 more
openaire   +1 more source