Results 221 to 230 of about 44,461 (250)

Double immune reconstitution therapy: Cladribine after alemtuzumab in the treatment of multiple sclerosis

European Journal of Neurology, 2021
AbstractBackground and purposeAlemtuzumab, a monoclonal anti‐CD52 antibody, and cladribine, a purine nucleoside analogue, are used for the treatment of highly active relapsing‐remitting multiple sclerosis (MS). Both are administered as two short yearly courses but possess the ability to induce long‐term remission, labeling them as immune reconstitution
Ivan Adamec, Ivan Jovanović, Magdalena Krbot Skorić, Mario Habek   +3 more
openaire   +3 more sources

Immune Reconstitution in HIV-1-Infected Individuals Treated with Potent Antiretroviral Therapy [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2001
Potent combination antiretroviral therapy that was introduced in the mid-1990s for treatment of HIV-1 infection has resulted in unprecedented decreases in HIV-1 replication and increases in CD4+ T cell counts in many individuals. Coincident with the introduction of potent combination antiretroviral therapy, substantial declines in AIDS-related ...
Elizabeth Connick
exaly   +3 more sources

Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection

Blood, 2011
AbstractAlthough highly active antiretroviral therapy has enabled constant progress in reducing HIV-1 replication, in some patients who are “aviremic” during treatment, the problem of insufficient immune restoration remains, and this exposes them to the risk of immune deficiency–associated pathologies.
Corbeau, P., Reynes, J.
openaire   +2 more sources

Immune reconstitution in lymphoid tissue following potent antiretroviral therapy

Clinical Immunology Newsletter, 1999
Abstract During untreated HIV-1 infection, a chronic state of immune activation and inflammation develops at the lymphoid tissue sites of viral replication. The early effect of potent combination drug therapy is a reduction in peripheral viral burden and a reduction in the production of inflammatory and type 1 cytokines.
Jan Andersson, Thomas E. Fehniger
openaire   +1 more source

Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy

Current HIV/AIDS Reports, 2007
Patients with HIV infection who were very immunodeficient before achieving a virologic response to antiretroviral therapy (ART) may experience various disorders of immune reconstitution. Immune restoration disease occurs in approximately 10% to 50% of patients and results from the restoration of a pathogen-specific immune response that causes ...
openaire   +2 more sources

Immune reconstitution after a decade of combined antiretroviral therapies for human immunodeficiency virus

Trends in Immunology, 2011
The introduction of combined antiretroviral therapies (HAART) has reversed the fatal course of human immunodeficiency virus (HIV) infection. HAART controls virus production and, in most cases, allows the quantitative and functional immune defects caused by HIV to be reversed.
Amélie, Guihot, Anne, Bourgarit, Guislaine, Carcelain, Brigitte, Autran   +3 more
openaire   +2 more sources

Immune reconstitution in HIV-1 infection : the effects of antiretroviral and immune therapy

2011
This thesis presents findings from two randomised, controlled pilot studies, with nested sub-studies, an observational study, a compassionate release programme and a mortality audit. It aims to examine the effects, at a clinical and cellular level, of antiretroviral and immunotherapy in HIV-1 infection. Combination antiretroviral therapy (cART) enables
openaire   +1 more source

A tight match: comparing the effectiveness of immune reconstitution therapies for multiple sclerosis

Brain
This scientific commentary refers to ‘Haematopoietic stem cell transplant versus immune-reconstitution therapy in relapsing multiple sclerosis’ by Kalincik et al. (https://doi.org/10.1093/brain/awaf286).
Paolo A Muraro, Eleonora De Matteis, Antonio Scalfari   +2 more
openaire   +2 more sources

Effects of antiretroviral therapy on immune reconstitution.

Antiviral therapy, 2005
CD4 cell counts in human immunodeficiency virus (HIV)-infected patients increase under effective highly active antiretroviral therapy (HAART). Similar kinetics of response is observed irrespective of the stage of infection in which HAART is initiated.
openaire   +1 more source

[Immune reconstituted inflammatory syndrome. Pitfalls of antiretroviral therapy].

MMW Fortschritte der Medizin, 2004
The pandemic HIV infection, the more frequent use of immunosuppressive treatment, and the improved long-term prognosis of immunocompromised patients due to better supporting therapies have resulted in an increase in the prevalence of immunodeficiencies. Highly active antiretroviral therapy (HAART) can improve immunocompetence in HIV patients, even when
M, Stoll, H, Heiken, K, Weber, M, Hundt, G, Behrens, R E, Schmidt   +5 more
openaire   +1 more source