Results 51 to 60 of about 1,062,719 (316)
Arginine depletion as a mechanism for the immune privilege of corneal allografts. [PDF]
, 2011 The cornea is an immune privileged tissue. Since arginase has been found to modulate T-cell function by depleting arginine, we investigated the expression of arginase in the cornea and its possible role in immune privilege using a murine transplant model.
Larkin, Daniel FP +28 more
core +1 more source
Immune checkpoint receptors: homeostatic regulators of immunity [PDF]
Hepatology International, 2018 Alcoholic liver disease (ALD) is an escalating global problem accounting for more than 3 million deaths annually. Bacterial infections are diagnosed in 25-47% of hospitalized patients with cirrhosis and represent the most important trigger for acute decompensation, multi-organ failure, septic shock and death.
Antonio Riva, Shilpa Chokshi
openaire +3 more sources
Microbial-immune cross-talk and regulation of the immune system
, 2012 We are all born germ-free. Following birth we enter into a lifelong relationship with microbes residing on our body's surfaces. The lower intestine is home to the highest microbial density in our body, which is also the highest microbial density known on
Kathy D. McCoy +5 more
core +1 more source
Journal for ImmunoTherapy of CancerBackground Public neoantigens, including KRAS, TP53, and PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity and offer great promise for cancer immunotherapy.
Wang Wang +12 more
doaj +1 more source
Shaping of Intestinal Microbiota in Nlrp6- and Rag2-Deficient Mice Depends on Community Structure
Cell Reports, 2017 Contradicting observations have been made regarding the relative contributions of immune sensors to shaping the microbiome, yet the reasons for these discrepancies are not fully understood.
Eric J.C. Gálvez +4 more
doaj +1 more source
Immune System Modulations by Products of the Gut Microbiota
, 2020 The gut microbiota, which consists of all bacteria, viruses, fungus, and protozoa living in the intestine, and the immune system have co-evolved in a symbiotic relationship since the origin of the immune system.
Jean Dubé +3 more
core +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Testing the theory of immune selection in cancers that break the rules of transplantation
, 2009 Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance.
Fassati, A. +3 more
core +1 more source
Cell Reports, 2013 There is increasing interest in the chronic lymphocytic leukemia (CLL) microenvironment and the mechanisms that may promote CLL cell survival and proliferation.
Audun Os +8 more
doaj +1 more source
Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation
Biomolecules, 2020 Transforming growth factor beta 1 (TGF-β1) is an immunosuppresive cytokine that plays an essential role in immune homeostasis. It is well known that regulatory T (Treg) cells express TGF-β1; however, the role of autocrine TGF-β1 in the development ...
Garam Choi +4 more
doaj +1 more source