Results 91 to 100 of about 1,393,861 (205)

Challenges and opportunities of liver xenotransplantation

生物医学转化
Organ transplantation is the most effective treatment for end-stage organ failure. However, donor shortage leads to many patients dying while waiting for transplants.
Tang Xiao, Wang Liaoran, Zheng Shusen, Wang Kai, Xu Xiao   +4 more
doaj   +1 more source

Circular RNA MAP2K2‐modified immunosuppressive dendritic cells for preventing alloimmune rejection in organ transplantation

Bioengineering & Translational Medicine
Long‐term patient and graft survival has been achieved in organ transplantation but at the expense of toxic side effects that are associated with long‐term use of nonspecific immunosuppressive drugs.
Shuailong Li, Amal Abu Omar, Adam Greasley, Bowen Wang, Tan Ze Wang, Serina Chahal, Raj Kumar Thapa, Douglas Quan, Anton Skaro, Kexiang Liu, Xiufen Zheng   +10 more
doaj   +1 more source

Hypoxia-induced PD-L1 expression and modulation of muscle stem cell allograft rejection

Frontiers in Pharmacology
Stem cell therapy has shown immense promise in treating genetic disorders, particularly muscular diseases like Duchenne muscular dystrophy (DMD).
Jacob Raiten, Genevieve M. Abd, Shane B. Handelsman, Harshank V. Patel, Jennifer C. Ku, Agata M. Parsons, Jonathan L. Wassink, Sheridan L. Hayes, Juliana Overbay, Yong Li   +9 more
doaj   +1 more source

C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via selective activation of monocyte subsets

Journal of Advanced Research
Introduction: Despite advancements in transplant immunology and vascularized composite allotransplantation (VCA), the longevity of allografts remains hindered by the challenge of allograft rejection.
Jurij Kiefer, Johannes Zeller, Laura Schneider, Julia Thomé, James D. McFadyen, Isabel A. Hoerbrand, Friederike Lang, Emil Deiss, Balázs Bogner, Anna-Lena Schaefer, Nina Chevalier, Verena K. Horner, Sheena Kreuzaler, Ulrich Kneser, Martin Kauke-Navarro, David Braig, Kevin J. Woollard, Bohdan Pomahac, Karlheinz Peter, Steffen U. Eisenhardt   +19 more
doaj   +1 more source

Mixed rejection in heart transplantation

, 2023
reservedIntroduzione. Le due principali tipologie di rigetto acuto nei pazienti cardiotrapiatati sono quello cellulare e quello anticorpo-mediato o umorale, ma ne esiste un terzo chiamato rigetto misto, in cui sono presenti contemporaneamente nella ...
CONFENTE, ALESSANDRO
core  

Tacrolimus Maintains the Balance of Neutrophil Extracellular Traps by Inducing DNA Methylation of Neutrophils to Reduce Immune Rejection. [PDF]

Life (Basel), 2023
Xu L, Cai M.
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine
Transplantation of insulin‐producing cells derived from pluripotent stem cells represents a highly promising approach for the radical treatment of type 1 diabetes (T1D).
Zifan Li, Yu Kang, Yuyu Niu
doaj   +1 more source

Single-cell transcriptomics unravels the early immune landscape of renal allograft rejection and nominates Ccl3-Ccr5 as a therapeutic target

Frontiers in Immunology
BackgroundAcute rejection is a significant cause of impaired graft survival in the early post-transplantation period, and the early-stage immune cell dynamics with local intercellular communication during this process require further elucidation ...
Fanchao Wei, Zhaoxiang Wang, Ruochen Qi, Jingliang Zhang, Shichao Han, Changhong Shi, Tong Lu, Zhite Zhao, Zhengxuan Li, Lang Li, Weijun Qin, Shuaijun Ma, Lijun Yang   +12 more
doaj   +1 more source

Phytohemaglutinin (PHA) Immune Challenge protocol [PDF]

, 2013
Protocol for administering a PHA immune challenge to nestlings and ...
Joe Casto, Nicole Gerlach
core  

Landscape of the immune infiltration and identification of molecular diagnostic markers associated with immune cells in patients with kidney transplantation

Scientific Reports
Rejection seriously affects the success of kidney transplantations. However, the molecular mechanisms underlying this rejection remain unclear. The GSE21374 and GSE36059 datasets were downloaded from the Gene Expression Omnibus (GEO) database.
Zhangxiao Xu, Xun Sun, Xiaobo Ma, Bo Tao, Jian Wu, Yunpeng He, Yuan Zhao, Hexiang Mao, Jie Yang, Dehui Jiang, Lijun Wang, Chao Song   +11 more
doaj   +1 more source