Results 101 to 110 of about 12,660,283 (403)
Scientific Reports, 2022 While number of studies have shown that biological sex is a risk factor in the incidence and severity of infection-induced inflammatory diseases, the underlying mechanisms are still poorly understood.
Maud Deny +5 more
doaj +1 more source
Structural cells are key regulators of organ-specific immune response
Nature, 2020 The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens 1 . Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute ...
Thomas Krausgruber +10 more
semanticscholar +1 more source
Environmental Circadian Disruption Elevates the IL-6 Response to Lipopolysaccharide in Blood [PDF]
, 2013 The immune system is regulated by circadian clocks within the brain and immune cells. Environmental circadian disruption (ECD), consisting of a 6-h phase advance of the light:dark cycle once a week for 4 weeks, elevates the inflammatory response to ...
Adams, Kandis L. +3 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
iScienceSummary: Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin.
Luna Minute +10 more
doaj +1 more source
Analysis of DNA Exchange Using Thymidine Analogs (ADExTA) in Trypanosoma cruzi
Bio-Protocol, 2018 Trypanosoma cruzi is a protozoan parasite belonging to the Trypanosomatidae family. Although the trypanosomatids multiply predominantly by clonal generation, the presence of DNA exchange in some of them has been puzzling researchers over the years ...
Marcelo da Silva +4 more
doaj +1 more source
Development of catecholamine and cortisol stress responses in zebrafish. [PDF]
, 2014 Both adrenal catecholamines and steroids are known to be involved in the stress response, immune function, blood pressure and energy homeostasis. The response to stress is characterized by the activation of the hypothalamus-pituitary-adrenal (HPA) axis ...
Dipple, Katrina M +4 more
core +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Pharmacological STING Activation Is a Potential Alternative to Overcome Drug-Resistance in Melanoma
Frontiers in Oncology, 2020 Melanoma is the most aggressive type of skin cancer and resistance to the conventional chemotherapy is the major cause for its poor prognosis. Metabolic perturbations leading to increased production of reactive oxygen species activate NRF2-dependent anti-
Sandhya Chipurupalli +5 more
doaj +1 more source
Autophagy, the innate immune response and cancer
Molecular Oncology, 2020 Autophagy is a cellular degradation and recycling system, which can interact with components of innate immune signalling pathways to enhance pathogen clearance, in both immune and nonimmune cells.
Chelsea Gerada, K. Ryan
semanticscholar +1 more source