Results 171 to 180 of about 12,342,164 (400)

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Brainstem catecholaminergic neurons induce torpor during fasting by orchestrating cardiovascular and thermoregulation changes

Nature Communications
Torpor, an adaptive hypometabolic state in response to fasting, is characterized by pronounced reductions in body temperature, heart rate, and thermogenesis.
Mingxiu Cheng, Meiqi Wang, Liang Wang, Fangfang Yin, Jiayi Shen, Xin Xing, Yuyan Shi, Zhiwei Liu, Ping Wu, Wenling Gao, Yanyan Fan, Peng Cao, Cheng Zhan   +12 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

THE IMMUNE RESPONSE OF RABBITS TOLERANT TO BOVINE SERUM ALBUMIN TO THE INJECTION OF OTHER HETEROLOGOUS SERUM ALBUMINS [PDF]

, 1961
William O. Weigle
openalex   +1 more source

CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE [PDF]

, 1968
J. F. A. P. Miller, G.F. Mitchell
openalex   +3 more sources

A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing

Nature Communications
Herpes simplex virus (HSV) causes significant health burden worldwide. Currently used antiviral drugs are effective but resistance can occur. Here, we report two high-affinity neutralizing nanobodies, namely Nb14 and Nb32, that target non-overlapping ...
Jing Hu, Haoyuan Tan, Meihua Wang, Shasha Deng, Mengyao Liu, Peiyi Zheng, Anmin Wang, Meng Guo, Jin Wang, Jiayin Li, Huanwen Qiu, Chengbing Yao, Zhongliang Zhu, Chaolu Hasi, Dongli Pan, Hongliang He, Chenghao Huang, Yuhua Shang, Shu Zhu, Tengchuan Jin   +19 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

THE PRIMARY IMMUNE RESPONSE IN MICE [PDF]

, 1968
Robert E. Franzl, Philip D. McMaster
openalex   +1 more source

Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation

Scientific Reports
Inoculation of Bothrops jararaca snake venom (BjV) induces thrombocytopenia in humans and various animal species. Although several BjV toxins acting on hemostasis have been well characterized in vitro, it is not known which one is responsible for ...
Marcelo Larami Santoro, Ana Teresa Azevedo Sachetto, Jaqueline Gomes Rosa, Ricardo José Soares Torquato, Débora Andrade-Silva, Dilza Trevisan-Silva, Cynthia Zaccanini de Albuquerque, Solange M. T. Serrano, Vânia Gomes de Moura Mattaraia, Aparecida Sadae Tanaka, Maria Elisa Peichoto   +10 more
doaj   +1 more source

Effects of Clostridium difficile on the human immune response [PDF]

, 2013
Clostridium difficile is a bacterium that is rapidly becoming a large issue in the medical community due to its tendency to infect hospital patients and its resistance to antibiotics.
McGovern, Mike
core   +1 more source