Results 51 to 60 of about 12,660,283 (403)

Crosstalk Between ER Stress, Autophagy and Inflammation

Frontiers in Medicine, 2021
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but also plays a critical role in sensing cellular stress and maintaining cellular homeostasis.
Sandhya Chipurupalli, Unni Samavedam, Nirmal Robinson   +2 more
doaj   +1 more source

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh, Ausar, Salvador F, Brookes, Roger H, Dockrell, Hazel M, Ha, Yukyung, Hakimi, Jalil, Hasija, Manvi, Rahman, Nausheen, Smith, Steven G, Todryk, Stephen M   +9 more
core   +1 more source

TIGIT predominantly regulates the immune response via regulatory T cells

Journal of Clinical Investigation
: Coinhibitory receptors are critical for the maintenance of immune homeostasis. Upregulation of these receptors on effector T cells terminates T cell responses, while their expression on Tregs promotes their suppressor function.
S. Kurtuluş, K. Sakuishi, S. Ngiow, Nicole Joller, Dewar Tan, M. Teng, M. Smyth, V. Kuchroo, A. Anderson   +8 more
semanticscholar   +1 more source

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression

Mediators of Inflammation, 2018
Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep.
Carolina Cubillos-Zapata, Enrique Hernández-Jiménez, José Avendaño-Ortiz, Victor Toledano, Anibal Varela-Serrano, Isabel Fernández-Navarro, Raquel Casitas, Carlos Carpio, Luis A. Aguirre, Francisco García-Río, Eduardo López-Collazo   +10 more
doaj   +1 more source

Rondonin: antimicrobial properties and mechanism of action

FEBS Open Bio, 2021
Infectious diseases are among the major causes of death in the human population. A wide variety of organisms produce antimicrobial peptides (AMPs) as part of their first line of defense.
Katie C. T. Riciluca, Ursula C. Oliveira, Ronaldo Z. Mendonça, José C. Bozelli Junior, Shirley Schreier, Pedro I. daSilva Junior   +5 more
doaj   +1 more source

Delayed development of the protective IL-17A response following a Giardia muris infection in neonatal mice [PDF]

, 2019
Giardia is an intestinal protozoan parasite that has the ability to infect a wide range of hosts, which can result in the clinical condition 'giardiasis'.
De Bosscher, Karolien, Gagnaire, Aurélie, Geldhof, Peter, Maertens, Brecht, Paerewijck, Oonagh   +4 more
core   +2 more sources

Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress‐targeted therapeutic inhibitors

Molecular Oncology, 2019
In malignant transformation, cellular stress‐response pathways are dynamically mobilized to counterbalance oncogenic activity, keeping cancer cells viable.
Matheus H. Dias, Cecília S. Fonseca, Julianna D. Zeidler, Layra L. Albuquerque, Marcelo S. daSilva, Eduardo Cararo‐Lopes, Marcelo S. Reis, Vincent Noël, Edmilson O. dosSantos, Ian A. Prior, Hugo A. Armelin   +10 more
doaj   +1 more source

Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host

, 2016
The cellular adaptive immune response plays a key role in resolving influenza infection. Experiments where individuals are successively infected with different strains within a short timeframe provide insight into the underlying viral dynamics and the ...
Ada W.C. Yan, Antia, Badovinac, Barber, Beauchemin, Blattman, Bocharov, Bodewes, Boianelli, Boon, Bortnick, Braciale, Brown, Brown, Bui, Cao, Carolan, Carpenter, Chao, Christensen, Crowe, Davenport, De Boer, Dobrovolny, Epstein, Faroudi, Grayson, Grebe, Greenbaum, Hancioglu, Handel, Hou, Iwasaki, James M. McCaw, Jameson, Jane M. Heffernan, Jodie McVernon, Kaech, Kaech, Karen L. Laurie, Kees, Komadina, Kreijtz, Kris, Kylie M. Quinn, Laurie, Laurie, Lee, Lehmann-Grube, Luciani, Luckheeram, Marchuk, Martin, McElhaney, McMichael, Mehlhop-Williams, Miao, Miao, Murali-Krishna, Nicole L. La Gruta, Nowak, Pawelek, Pengxing Cao, Petrie, Quinn, Rammensee, Selin, Shin, Smith, Smith, Smith, Sridhar, Steel, Sze, Tanchot, Terajima, Tscharke, van Stipdonk, Veiga-Fernandes, Veiga-Fernandes, Wells, Wherry, Wirth, Wodarz, Wodarz, Yan, Yap, Yewdell, Yewdell, Zarnitsyna, Zehn   +90 more
core   +1 more source

Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells [PDF]

, 2019
The gingival epithelium is a physical and immunological barrier to the microbiota of the oral cavity, which interact through soluble mediators with the immune cells that patrol the tissue at the gingival epithelium.
Bradshaw, David, Brown, Jason L., Butcher, John, Culshaw, Shauna, Delaney, Chris, Johnston, William, Khan, Shaz, Rajendran, Ranjith, Ramage, Gordon   +8 more
core   +4 more sources