Design and expression of TolC as a recombinant protein vaccine against Shigella flexneri and evaluation of immunogenic response in mice [PDF]
Background: Shigella is one of the major cause of dysenteric diarrhea, which is known shigelosis. Shigelosis causes 160,000 deaths annually of diarrheal disease in a global scale especially children less than 5 years old. No licensed vaccine is available against shigelosis, therefore, efforts for develop an effective and safe vaccine against shigella ...
arxiv
$L^2$-Riemann-Roch for singular complex curves [PDF]
We present a comprehensive $L^2$-theory for the $\overline\partial$-operator on singular complex curves, including $L^2$-versions of the Riemann-Roch theorem and some applications.
arxiv +1 more source
GeSERA: General-domain Summary Evaluation by Relevance Analysis [PDF]
We present GeSERA, an open-source improved version of SERA for evaluating automatic extractive and abstractive summaries from the general domain. SERA is based on a search engine that compares candidate and reference summaries (called queries) against an information retrieval document base (called index). SERA was originally designed for the biomedical
arxiv
Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of NOD mice to an inducer of accelerated diabetes [PDF]
One's present repertoire of antibodies encodes the history of one's past immunological experience. Can the present autoantibody repertoire be consulted to predict resistance or susceptibility to the future development of an autoimmune disease? Here we developed an antigen microarray chip and used bioinformatic analysis to study a model of type 1 ...
arxiv +1 more source
Strength and weakness of disease-induced herd immunity in networks [PDF]
When a fraction of a population becomes immune to an infectious disease, the population-wide infection risk decreases nonlinearly due to collective protection, known as herd immunity. Studies based on mean-field models suggest that natural infection in a heterogeneous population may induce herd immunity more efficiently than homogeneous immunization ...
arxiv
Tachyon Backgrounds in 2D String Theory [PDF]
We consider the construction of tachyonic backgrounds in two-dimensional string theory, focusing on the Sine-Liouville background. This can be studied in two different ways, one within the context of collective field theory and the other via the formalism of Toda integrable systems. The two approaches are seemingly different.
arxiv +1 more source
Matrix Model Maps and Reconstruction of AdS SUGRA Interactions [PDF]
We consider the question of reconstructing (cubic) SUGRA interactions in AdS/CFT. The method we introduce is based on the matrix model maps (MMP) which were previously successfully employed at the linearized level. The strategy is to start with the map for 1/2 BPS configurations which is exactly known (to all orders) in the hamiltonian framework.
arxiv +1 more source
Plasmodium knowlesi H strain pregnancy malaria immune responses in olive baboons (Papio anubis) [PDF]
Approximately 24 million pregnant women in Sub-Saharan Africa are at risk of suffering from pregnancy malaria complications. Mechanisms responsible for increased susceptibility to malaria in pregnant women are not fully understood. Baboons are susceptible to Plasmodium knowlesi and their reproductive physiology and host pathogen interactions are ...
arxiv
Cytokine expression in malaria-infected non-human primate placentas [PDF]
Malaria parasites are known to mediate the induction of inflammatory immune responses at the maternal-foetal interface during placental malaria (PM) leading to adverse consequences like pre-term deliveries and abortions. Immunological events that take place within the malaria-infected placental micro-environment leading to retarded foetal growth and ...
arxiv
Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires [PDF]
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, cancer, HIV).
arxiv +1 more source