Results 91 to 100 of about 6,143,524 (256)

Human inborn errors of immunity underlying Talaromyces marneffei infections: a multicenter, retrospective cohort study

Frontiers in Immunology
IntroductionTalaromyces marneffei (T. marneffei) infections in children can occur secondary to inborn errors of immunity (IEIs). We aimed to investigate the clinical and genetic features of T.
Huifeng Fan, Zhiyong Yang, Yuhui Wu, Xiulan Lu, Tian Li, Xuyang Lu, Gen Lu, Liming He, Guoping Lu, Li Huang   +9 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Effect of oak acorn level on colostrum composition and plasma immunoglobulin G of late-pregnant goats and their kids

Animal, 2018
Oak acorn contains high levels of tannins which have capacity to form complexes with proteins and consequently reduce their availability and as a result it could reduce colostrum quality and immunoglobulin (Ig) synthesis. Thus, the aim of this experiment
H. Jafari, F. Fatahnia, A. Khatibjoo, G. Taasoli, H. Fazaeli   +4 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Immune activity, body condition and human-associated environmental impacts in a wild marine mammal [PDF]

, 2013
PMB was funded by the Natural Environment Research Council (www.nerc.ac.uk), the Universities Federation for Animal Welfare (www.ufaw.org.uk) and the Sea Mammal Research Unit (www.smru.st-and.ac.uk).
Simon J Goodman, Ailsa J. Hall (29488), Patrick M Brock, Acevedo-Whitehouse, Karina, Brock, Patrick M., Goodman, Simon J., Patrick M. Brock (428558), Goodman, Simon J, Karina Acevedo-Whitehouse, Marilyn Cruz (428559), Hall, Ailsa J., Karina Acevedo-Whitehouse (408475), Ailsa J Hall, Marilyn Cruz, Simon J. Goodman (134273), Cruz, Marilyn, Brock, Patrick M, Hall, Ailsa J   +17 more
core   +2 more sources

Evaluation of Immune Status of Pigs against Classical Swine Fever for Three Years after the Initiation of Vaccination in Gifu Prefecture, Japan

Pathogens
In 2018, classical swine fever (CSF) reemerged in Gifu Prefecture, Japan, after 26 years of absence, and vaccination of domestic pigs using a live attenuated vaccine was initiated in 2019.
Keisuke Kuwata, Naotoshi Kuninaga, Yoko Kimura, Kohei Makita, Norikazu Isoda, Yukio Shimizu, Yoshihiro Sakoda   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source