Results 91 to 100 of about 2,089,667 (358)

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]

, 2014
BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
A D Beggs, A Merlo, AG Heriot, AM Wolf, C Evans, C Grunfeld, C Loddenkemper, CF Evans, D Kumar, DJ Needham, E Sato, F Balkwill, G Brandacher, G Galizia, G Pawelec, H Nakayama, IC Talbot, JC Harrison, JD Fontenot, JK Polansky, KE Sullivan, KJ Livak, KL Ling, L Xue, LA Liotta, LM Ebert, M Kanazawa, M Kim, M Morris, M Shibata, N Hiraoka, N Kobayashi, N Watanabe, P Quirke, P Radhakrishnan, P Salama, PJ Coffer, R Somasundaram, RJ O’Hara, S Hinz, S Hori, S K Ganapathi, S Ogino, S V Hodgson, SL Clarke, SM Phillips, T Blankenstein, T Sato, TJ Curiel, TJ Curiel, VC Petersen, W Zou, X Chen   +52 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Immunological aspects of HCV/HIV coinfection

Терапевтический архив, 2011
Aim. To evaluate effects of HCV/HIV coinfection on blood lymphocyte phenotype including cells CD56+. Material and methods. We studied standard immunogram, subpopulational composition and functional activity of blood cells CD56+ in 67 patients with ...
Nikolay Dmitrievich Yushchuk, Irina Viktorovna Shestakova, Irina Petrovna Balmasova, Mariya Vladimirovna Vysheslavtseva, Evgeniya Vasil'evna Shmeleva, N D Yuschuk, I V Shestakova, I P Balmasova, M V Vysheslavtseva, E V Shmeleva   +9 more
doaj  

Defective interfering virus protects elderly mice from influenza [PDF]

, 2011
Background: We have identified and characterised a defective-interfering (DI) influenza A virus particles containing a highly deleted segment 1 RNA that has broad-spectrum antiviral activity.
Scott, P. D. (Paul D.), Meng, Bo, Marriott, Anthony C., Easton, A. J. (Andrew J.), Dimmock, N. J.   +4 more
core   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Immunotropic effects of Curcuma longa extract as a component of original rectal suppositories in the dynamics of experimental Сrohn’s disease

Медицинская иммунология, 2020
Crohn’s disease is an urgent problem of modern gastroenterology due to increasing prevalence, severity of complications and side effects of the basic therapy, in particular upon treatment with 5-aminosalicylic acid (5-ASA).
М. V. Osikov, Е. V. Simonyan, A. E. Bakeeva, O. I. Ogneva   +3 more
doaj   +1 more source

Effects of immune supplementation and immune challenge on oxidative status and physiology in a model bird:implications for ecologists [PDF]

, 2010
One route to gain insight into the causes and consequences of ecological differentiation is to understand the underlying physiological mechanisms. We explored the relationships between immunological and oxidative status and investigated how birds cope ...
Adler, Alberti, Alonso-Alvarez, Ames, Barja, Beckman, Bertrand, Bond, Brand, Brundige, Calder, Cerven, Cohen, Cohen, Cohen, Cohen, Cohen, Costantini, Costantini, Costantini, Costantini, Costantini, Costantini, Delers, Demas, Dobryszycka, Dowling, Exton, Finkel, Gavilanes, Gessaman, Gutteridge, Halliwell, Halliwell, Hansen, Hansen, Herrero, Hill, Humphrey, Hõrak, Hõrak, Iamele, Ji, Jollès, Klebanoff, Klockars, Körmöczi, Lasiewski, Lavoie, Lee, Leeuwenburgh, Liu, Matson, Matson, Matson, McEwen, Millet, Monaghan, Nomoto, Norris, Ohno, Ots, Pérez-Rodríguez, Raetz, Rasbash, Rodnan, Roura, Råberg, Saino, Saino, Salvante, Sava, Siwicki, Speakman, Speijers, Tieleman, Tieleman, Torres, Tummeleht, Wagner   +79 more
core   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source