Results 71 to 80 of about 6,143,524 (256)

Clinical diagnostic criteria of efficiency for combined etiopathogenetic therapy in patients with chronic Epstein–Barr virus infection

Инфекция и иммунитет, 2020
Treatment of chronic viral infections accompanied by permanent virus persistence in the target epitopes of the oral cavity, skin, urogenital tract is complicated by virtual lack of available drugs exerting combined systemic virulicidal and ...
V. A. Zurochka, O. I. Zabkov, M. A. Dobrynina, V. F. Gritsenko, E. V. Davydova, A. V. Chukichev, N. A. Zabokritskii, A. P. Sarapultsev, A. V. Zurochka   +8 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection. [PDF]

, 2010
BACKGROUND: An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology.
Veenemans, J., Chilongola, Jaffu O, Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Savelkoul, Huub FJ, Hans Verhoef, Matthew McCall, Jaffu O Chilongola, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Chilongola Jaffu O, Erasto V Mbugi, Savelkoul Huub FJ, Chilongola, J.O., John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Chilongola, J., Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +41 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Multi-Layered Immune Inspired Approach to Data Mining [PDF]

, 2002
A Multi-Layered Immune Inspired Approach to Data Mining. Thomas Knight and Jon Timmis Computing Laboratory University of Kent at Canterbury. CT2 7NF.
Timmis, Jon, Thomas Knight, Jon Timmis, Knight, Thomas   +3 more
core  

Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. [PDF]

, 2012
BACKGROUND:  Schistosomiasis elicits cross-regulatory immune responses, but it is unclear how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters
Rujeni, N, Nausch, N, Mitchell, KM, Mutapi, Francisca, Appleby, Laura J, Midzi, Nicholas, Rujeni, Nadine, Bourke, Claire D, Mduluza, Takafira, Nausch, Norman, Appleby, LJ, Mduluza, T, Midzi, N, Mutapi, F, Bourke, CD, Mitchell, Kate M   +15 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

aiVIS - Artificial Immune Network Visualisation [PDF]

, 2001
The field of Artificial Immune Systems (AIS) is the use of the natural immune system as a metaphor for solving computational problems. A novel unsupervised machine-learning algorithm, inspired by the immune system, has been developed called AINE.
Timmis, Jon
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Immunological aspects of HCV/HIV coinfection

Терапевтический архив, 2011
Aim. To evaluate effects of HCV/HIV coinfection on blood lymphocyte phenotype including cells CD56+. Material and methods. We studied standard immunogram, subpopulational composition and functional activity of blood cells CD56+ in 67 patients with ...
Nikolay Dmitrievich Yushchuk, Irina Viktorovna Shestakova, Irina Petrovna Balmasova, Mariya Vladimirovna Vysheslavtseva, Evgeniya Vasil'evna Shmeleva, N D Yuschuk, I V Shestakova, I P Balmasova, M V Vysheslavtseva, E V Shmeleva   +9 more
doaj