Results 61 to 70 of about 6,143,524 (256)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

GENETIC AND INFECTIOUS MARKERS OF INFERTILITY

open access: yesИнфекция и иммунитет, 2018
The report presents the results of own research of the most important factors in the genesis of various forms of sterility. A  married couples (n = 50) was examined with regard to possible  etiological structure of these forms of pathology — infections ...
E. A. Levkova   +3 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Surgical site infection in HIV-positive patients with chronic spondylitis

open access: yesИнфекция и иммунитет
Introduction. The epidemic process of medical care-related infections complies to the general laws for development of epidemic process, although it has specific features.
Ya. A. Aitova   +7 more
doaj   +1 more source

Alleviation of thermal and overcrowding stress in finishing broilers by dietary propolis supplementation

open access: yesItalian Journal of Animal Science, 2018
The current study investigated the efficacy of propolis supplementation (bee glue; BG) on ameliorating overcrowding and heat stress-induced impairment of growth performance, immunity, some stress indicators, and jejunum morphology in broilers.
Shaban Chegini, Ali Kiani, Hassan Rokni
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Phytohemaglutinin (PHA) Immune Challenge protocol [PDF]

open access: yes, 2013
Protocol for administering a PHA immune challenge to nestlings and ...
Joe Casto, Nicole Gerlach
core  

DataSheet1_Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma.PDF

open access: yes, 2022
Introduction: Increasing evidences have shown that hypoxia and the immune microenvironment play vital roles in the development of osteosarcoma. However, reliable gene signatures based on the combination of hypoxia and the immune status for prognostic ...
Wenshuo Zhang (164908)   +5 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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