Results 111 to 120 of about 2,089,667 (358)

Effects of drinking water, sanitation, handwashing, and nutritional interventions on immune status in young children: a cluster-randomized controlled trial in rural Bangladesh [PDF]

, 2021
Audrie Lin, Andrew Mertens, Sophia T. Tan, Md Ziaur Rahman, Lisa Hester, Lisa E. Kim, Benjamin F. Arnold, Md. Rabiul Karim, Sunny Shahriar, Shahjahan Ali, Abul K Shoab, Md Saheen Hossen, Palash Mutsuddi, Syeda L Famida, Salma Akther, Mahbubur Rahman, Leanne Unicomb, Zachary Butzin-Dozier, Caitlin Hemlock, Alan Hubbard, Christine P. Stewart, Lia C. H. Fernald, John M. Colford, Stephen P. Luby, Firdaus S. Dhabhar   +24 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Supplementary Figure 1 from The Human <i>TLR</i> Innate Immune Gene Family Is Differentially Influenced by DNA Stress and <i>p53</i> Status in Cancer Cells

, 2023
Maria Shatz, Daniel Menéndez, Michael A. Resnick   +2 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EFFICIENCY AND SAFETY OF MELATONIN ADMINISTRATION IN THE PATIENTS WITH ATOPIC DERMATITIS

Медицинская иммунология, 2014
. The objective of this study was to determine efficacy and safety of melatonin administered in addition to conventional atopic dermatitis treatment. Study design: open randomized parallel group study.
V. S. Shirinsky, V. M. Nepomnyashikh, M. I. Leonova, O. L. Krugleeva, V. S. Kozhevnikov, N. Yu. Solovyova, A. V. Shurlygina, G. I. Litvinenko, I. V. Shirinsky, O. A. Malysheva   +9 more
doaj   +1 more source

Figure S4 from PD-L1 Negative Status is Associated with Lower Mutation Burden, Differential Expression of Immune-Related Genes, and Worse Survival in Stage III Melanoma

, 2023
Jason Madore, Dario Strbenac, Ricardo E. Vilain, Alexander M. Menzies, Jeen Y. H. Yang, John F. Thompson, Georgina V. Long, Graham J. Mann, Richard A. Scolyer, James S. Wilmott   +9 more
openalex   +1 more source

Promising Therapeutic Impact of Immune Checkpoint Inhibitors in Type II Endometrial Cancer Patients with Deficient Mismatch Repair Status [PDF]

, 2023
Kiyoka Sawada, Kentaro Nakayama, Sultana Razia, Hitomi Yamashita, Tomoka Ishibashi, Masako Ishikawa, Kosuke Kanno, Seiya Sato, Satoru Nakayama, Yoshiro Otsuki, Satoru Kyo   +10 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Supplemental Figure 1. Age, gender, MCPyV status and perineural invasion do not correlate with disease specific survival in MCC. from Density, Distribution, and Composition of Immune Infiltrates Correlate with Survival in Merkel Cell Carcinoma

, 2023
Laurence Feldmeyer, Courtney W. Hudgens, Genevieve Ray-Lyons, Priyadharsini Nagarajan, Phyu P. Aung, Jonathan L. Curry, Carlos A. Torres‐Cabala, Barbara Mino, Jaime Rodriguez‐Canales, Alexandre Reuben, Pei-Ling Chen, Jennifer S. Ko, Steven D. Billings, Roland L. Bassett, Ignacio I. Wistuba, Zachary A. Cooper, Víctor G. Prieto, Jennifer A. Wargo, Michael T. Tetzlaff   +18 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source