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The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were the first to identify immune responses to be under a circadian control. Only in the last decade, however, have the molecular factors governing circadian immune rhythms been identified.
Wang, Chen+3 more
openaire +3 more sources
Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves’ Disease [PDF]
Background An excess of thyroid hormones in Graves’ disease (GD) has profound effects on systemic energy metabolism that are currently partially understood.
Ho Yeop Lee+9 more
doaj +1 more source
Immunological Aspects of Isolation and Confinement
Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general.
Sergey Ponomarev+5 more
doaj +1 more source
The extracellular matrix and the immune system: A mutually dependent relationship
For decades, immunologists have studied the role of circulating immune cells in host protection, with a more recent appreciation of immune cells resident within the tissue microenvironment and the intercommunication between nonhematopoietic cells and ...
T. Sutherland, D. Dyer, J. Allen
semanticscholar +1 more source
Pathophysiology of Inflammatory Bowel Disease: Innate Immune System
Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause.
Angela Sáez+4 more
semanticscholar +1 more source
The impact of short-term confinement on human innate immunity
During space missions cosmonauts are exposed to a myriad of distinct stressors such as radiation, overloads, weightlessness, radiation, isolation in artificial environmental conditions, which causes changes in immune system.
S. A. Ponomarev+10 more
doaj +1 more source
Immunosenescence and exhaustion are involved in the development and progression of type 2 diabetes (T2D) and metabolic liver diseases, including fatty liver, fibrosis, and cirrhosis, in humans.
Byeong Chang Sim+11 more
doaj +1 more source
Mitochondrial Metabolic Signatures in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. HCC progression and metastasis are closely related to altered mitochondrial metabolism, including mitochondrial stress responses, metabolic reprogramming, and ...
Ho-Yeop Lee+3 more
doaj +1 more source
The roles of extracellular vesicles in the immune system
Extracellular vesicles (EVs) are increasingly recognized as having ubiquitous roles in the immune system. This Review focuses on the progress made in the field in the past 5 years, including the roles of EVs in innate and adaptive immunity and their ...
E. Buzás
semanticscholar +1 more source
Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways
Measurement(s) molecules per cell Technology Type(s) nanoflow high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry Sample Characteristic - Organism Mus ...
Nathan P. Manes+6 more
doaj +1 more source