Results 1 to 10 of about 1,872,951 (268)

Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA

Nature Communications
The immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine ...
Julia L. Gross, Rahul Basu, Clinton J. Bradfield, Jing Sun, Sinu P. John, Sanchita Das, John P. Dekker, David S. Weiss, Iain D. C. Fraser   +8 more
doaj   +1 more source

Lipopolysaccharides from Microcystis Cyanobacteria-Dominated Water Bloom and from Laboratory Cultures Trigger Human Immune Innate Response

Toxins, 2019
Massive toxic blooms of cyanobacteria represent a major threat to water supplies worldwide. Here, the biological activities of lipopolysaccharide (LPS) isolated from Microcystis aeruginosa, the most prominent cyanobacteria in water bloom, were studied ...
Zdena Moosová, Lenka Šindlerová, Barbora Ambrůzová, Gabriela Ambrožová, Ondřej Vašíček, Mirna Velki, Pavel Babica, Lukáš Kubala   +7 more
doaj   +1 more source

Nitric Oxide and Electrophilic Cyclopentenone Prostaglandins in Redox signaling, Regulation of Cytoskeleton Dynamics and Intercellular Communication

Frontiers in Cell and Developmental Biology, 2021
Nitric oxide (NO) and electrophilic cyclopentenone prostaglandins (CyPG) are local mediators that modulate cellular response to oxidative stress in different pathophysiological processes. In particular, there is increasing evidence about their functional
Ángel Bago, Miguel A. Íñiguez, Miguel A. Íñiguez, Juan M. Serrador   +3 more
doaj   +1 more source

Conserved biophysical compatibility among the highly variable germline-encoded regions shapes TCR-MHC interactions

eLife, 2023
T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges.
Christopher T Boughter, Martin Meier-Schellersheim   +1 more
doaj   +1 more source

Pain and the immune system [PDF]

British Journal of Anaesthesia, 2008
In inflammation, leucocytes containing opioid peptides migrate into the tissue. Opioid peptides can be released and bind to opioid receptors on peripheral nerve terminals, which counteracts inflammatory pain. Migration of opioid peptide-containing leucocytes is controlled by chemokines and adhesion molecules.
H L, Rittner, A, Brack, C, Stein
openaire   +2 more sources

Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells

BMC Biology
Background Melanoma is one of the most commonly diagnosed malignancies and serves as a model for studying immunotherapy. The B16 melanoma model, resembling human cold tumors that lack T cell infiltration and show minimal response to PD-1 blockade, is ...
Rong Huang, Yingbin Wang, Haitao Teng, Mengjun Xu, Kexin He, Yingzhuo Shen, Guo Guo, Xinyu Feng, Tianhan Li, Binhui Zhou, Marc Bajenoff, Toby Lawrence, Yinming Liang, Liaoxun Lu, Lichen Zhang   +14 more
doaj   +1 more source

Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota

mSystems, 2017
The bodies of mammals are hosts to vast microbial communities composed of trillions of bacteria from thousands of species, whose effects on health and development have begun to be appreciated only recently.
Nathan P. Manes, Natalia Shulzhenko, Arthur G. Nuccio, Sara Azeem, Andrey Morgun, Aleksandra Nita-Lazar   +5 more
doaj   +1 more source

A systems approach for elucidating the role of the microbiome in epigenetic cellular memory

mSystems
The microbiome plays an essential role in the development of the immune system. Both the immune system and microbiome dynamically respond to internal and external cues, and dysregulation of either of these systems can lead to disease pathology.
Jacob W. Pederson, Aleksandra Nita-Lazar
doaj   +1 more source

ADHESION OF PATHOGENIC BACTERIA TO POLYSTYRENE, SKIN AND GUT MUCUS OF GILTHEAD SEABREAM, INFECTIOUS CAPACITY AND ANTIBIOTICS SUSCEPTIBILITY

Boletim do Instituto de Pesca, 2019
Linking proprieties of adhesion, infectious capacities and antibiotic resistance of pathogen bacteria could help to treat fish diseases. Adhesions of ten fish pathogenic bacteria were tested in microtiter plates vacant, coated with skin or gut mucus ...
Said Ben Hamed, Francisco Guardiola, Patricia Morcillo, Pilarga González-Párraga, Maria José Tavares Ranzani-Paiva, María Ángeles Esteban   +5 more
doaj   +1 more source

Author Correction: Effects of wound dressings containing silver on skin and immune cells

Scientific Reports, 2021
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Kristina Nešporová, Vojtěch Pavlík, Barbora Šafránková, Hana Vágnerová, Pavel Odráška, Ondřej Žídek, Natálie Císařová, Svitlana Skoroplyas, Lukáš Kubala, Vladimír Velebný   +9 more
doaj   +1 more source