Results 21 to 30 of about 25,098,294 (334)
The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion
Frontiers in Immunology, 2022 Exhausted CD8+ T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic infections and cancers.
Andrea C. Pichler +3 more
doaj +1 more source
Frontiers in Immunology, 2014 Natural killer (NK) cells play an essential role in the fight against tumor development. Over the last years, the progress made in the NK cell biology field and in deciphering how NK cell function is regulated, is driving efforts to utilize NK cell-based
Cristina eEguizabal +11 more
doaj +1 more source
Normalizing and denoising protein expression data from droplet-based single cell profiling
Nature Communications, 2022 Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè +2 more
doaj +1 more source
RANKL biology: bone metabolism, the immune system, and beyond
Inflammation and Regeneration, 2020 Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/macrophage–lineage cells into the bone–resorbing cells called osteoclasts.
T. Ono +3 more
semanticscholar +1 more source
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
Nature Reviews Endocrinology, 2020 Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that autoreactive T cells mistakenly destroy healthy (‘innocent’) β-cells.
B. Roep +3 more
semanticscholar +1 more source
T-Cell Senescence in Human Metabolic Diseases [PDF]
Diabetes & Metabolism JournalImmunosenescence denotes a state of dysregulated immune cell function characterized by a confluence of factors, including arrested cell cycle, telomere shortening, markers of cellular stress, mitochondrial dysfunction, loss of proteostasis, epigenetic ...
Ha Thi Nga +2 more
doaj +1 more source
eLife, 2023 T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges.
Christopher T Boughter +1 more
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Interactions Between the Microbiota and the Immune System
Science, 2012 The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out functions that are critical for host physiology, they nevertheless pose the ...
L. Hooper, D. Littman, A. Macpherson
semanticscholar +1 more source
Gut Microbiota and Immune System Interactions
Microorganisms, 2020 Dynamic interactions between gut microbiota and a host’s innate and adaptive immune systems play key roles in maintaining intestinal homeostasis and inhibiting inflammation.
Ji Youn Yoo +4 more
semanticscholar +1 more source
Differences in Type 2 Fiber Composition in the Vastus Lateralis and Gluteus Maximus of Patients with Hip Fractures [PDF]
Endocrinology and MetabolismBackground Aging leads to sarcopenia, which is characterized by reduced muscle mass and strength. Many factors, including altered muscle protein turnover, diminished neuromuscular function, hormonal changes, systemic inflammation, and the structure and ...
Jingwen Tian +11 more
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