Results 21 to 30 of about 27,772,960 (260)

Mapping the developing human immune system across organs

bioRxiv, 2022
Recent advances in single cell genomics technologies have facilitated studies on the developing immune system at unprecedented scale and resolution. However, these studies have focused on one or a few organs and were thus limited in understanding the ...
Chenqu Suo, E. Dann, Issac Goh, Laura Jardine, Vitalii Kleshchevnikov, Jong-Eun Park, R. Botting, Emily Stephenson, J. Engelbert, Z. Tuong, K. Polański, Nadav Yayon, Chuan Xu, Ondrej Suchanek, R. Elmentaite, C. Conde, Peng He, S. Pritchard, M. Miah, C. Moldovan, Alexander S Steemers, M. Prete, J. Marioni, M. Clatworthy, M. Haniffa, S. Teichmann   +25 more
semanticscholar   +1 more source

Peripheral and central immune system crosstalk in Alzheimer disease — a research prospectus

Nature Reviews Neurology, 2021
Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a considerable body of evidence indicates pathological alterations in central and peripheral immune responses that change over time.
B. Bettcher, M. Tansey, G. Dorothée, M. Heneka   +3 more
semanticscholar   +1 more source

Obesity, Inflammation, and Immune System in Osteoarthritis

Frontiers in Immunology, 2022
Obesity remains the most important risk factor for the incidence and progression of osteoarthritis (OA). The leading cause of OA was believed to be overloading the joints due to excess weight which in turn leads to the destruction of articular cartilage.
Udhaya Nedunchezhiyan, I. Varughese, A. Sun, Xiaoxin Wu, R. Crawford, I. Prasadam   +5 more
semanticscholar   +1 more source

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

Nutrients, 2020
Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including ...
A. Gombart, A. Pierre, S. Maggini
semanticscholar   +1 more source

Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

Nutrients, 2020
The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization. Challenges arise concerning how to optimally support the immune system in the general population, especially under self-confinement.
M. Iddir, Alex Brito, Giulia Dingeo, Sofia Sosa Fernandez Del Campo, H. Samouda, Michael R. La Frano, T. Bohn   +6 more
semanticscholar   +1 more source

The interaction of innate immune and adaptive immune system

MedComm
The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll‐like receptors to detect pathogens and initiate rapid response mechanisms.
Ruyuan Wang, Caini Lan, K. Benlagha, Niels Olsen Saraiva Câmara, Heather Miller, Masato Kubo, Steffen Heegaard, Pamela Lee, Lu Yang, Huamei Forsman, Xingrui Li, Zhimin Zhai, Chaohong Liu   +12 more
semanticscholar   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Bifidobacteria-mediated immune system imprinting early in life

bioRxiv, 2020
Immune-microbe interactions early in life influence an individual’s risk of developing allergies, asthma and some autoimmune disorders. Breastfeeding helps guide the development of healthy immune-microbe relationships, in part by providing nutrients to ...
B. Henrick, L. Rodriguez, T. Lakshmikanth, Christian Pou, E. Henckel, E. Henckel, E. Henckel, Axel Olin, Jun Wang, J. Mikeš, Ziyang Tan, Yang Chen, Amy M. Ehrlich, A. Bernhardsson, C. Mugabo, Ylva Ambrosiani, A. Gustafsson, A. Gustafsson, Stephanie Chew, H. Brown, Johann Prambs, Kajsa Bohlin, Kajsa Bohlin, Ryan D. Mitchell, M. Underwood, J. Smilowitz, J. German, S. Frese, P. Brodin, P. Brodin   +29 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Frontiers in Immunology, 2020
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM).
Gholamreza Daryabor, M. Atashzar, D. Kabelitz, S. Meri, K. Kalantar   +4 more
semanticscholar   +1 more source