Results 31 to 40 of about 3,160,474 (348)
The aging of the immune system [PDF]
Transplant International, 2009 An age-related decline in immune functions, referred to as immunosenescence, is partially responsible for the increased prevalence and severity of infectious diseases, and the low efficacy of vaccination in elderly persons. Immunosenescence is characterized by a decrease in cell-mediated immune function as well as by reduced humoral immune responses ...
Daniela, Weiskopf +2 more
openaire +2 more sources
OMiCC: An expanded and enhanced platform for meta-analysis of public gene expression data
STAR Protocols, 2022 Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis ...
Candace C. Liu +5 more
doaj +1 more source
Fresh Insights into Disease Etiology and the Role of Microbial Pathogens. [PDF]
, 2016 Pathogens have been implicated in the initiation and/or promotion of systemic sclerosis (scleroderma, SSc); however, no evidence was found to substantiate the direct contribution to this disease in past years.
FARINA, Antonella, Farina, G.a.2.
core +1 more source
Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth. [PDF]
, 2013 Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates ...
Bensinger, Steven J, York, Autumn G
core +1 more source
IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses
eLife, 2019 Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined.
Rachel A Gottschalk +10 more
doaj +1 more source
Cell Reports, 2022 Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John +13 more
doaj +1 more source
Rejuvenating the immune system. [PDF]
Mol OncolRejuvenation of elementary immune system components has emerged as a promising strategy to deal with increased susceptibility to infections, cancers, autoimmune disorders, and low efficacy to vaccines, frequently accompanying aging. In this context, the thymus has gained significant attention. A recent study by Santamaria et al.
Evangelou K, Gorgoulis VG.
europepmc +5 more sources
Immunization and Aging: a Learning Process in the Immune Network
, 1998 The immune system can be thought as a complex network of different interacting elements. A cellular automaton, defined in shape-space, was recently shown to exhibit self-regulation and complex behavior and is, therefore, a good candidate to model the ...
A. Coutinho +12 more
core +1 more source
The immune system in chickens , [PDF]
Avian Pathology, 1974 The most sophisticated feature of the immune system expressed in vertebrates is recognition of foreign molecules by distinct types of immunocompetent cells. Birds are the first vertebrates in which a clear dichotomy of the lymphoid system has been established: 1. Thymus-derived (T) lymphocytes, the effector cells in cell-mediated (immunity and 2. Bursa-
openaire +2 more sources
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease
Molecular Neurodegeneration, 2022 Background The implication of gut microbiota in the control of brain functions in health and disease is a novel, currently emerging concept.
Diane Bairamian +6 more
doaj +1 more source