Results 51 to 60 of about 25,098,294 (334)
Medicine Science, 2023 Kyrgyzstan's challenging natural conditions and fragile mountain ecosystems can weaken the immune system of individuals residing permanently in high-altitude areas.
Nasira Tiumonbaeva +3 more
doaj +1 more source
FEBS Letters, EarlyView.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
Nature CommunicationsThe immunologic consequences of using bactericidal versus bacteriostatic antibiotic treatments are unclear. We observed a bacteriostatic (growth halting) treatment was more protective than a bactericidal (bacteria killing) treatment in a murine ...
Julia L. Gross +8 more
doaj +1 more source
Roles of the immune system in cancer: from tumor initiation to metastatic progression
Genes & Development, 2018 In this review, Gonzelez et al. provide an update of recent accomplishments, unifying concepts, and futures challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.
Hugo Gonzalez, C. Hagerling, Z. Werb
semanticscholar +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Frontiers in Immunology, 2019 Xlf/Cernunnos is unique among the core factors of the non-homologous end joining (NHEJ) DNA double strand breaks (DSBs) repair pathway, in the sense that it is not essential for V(D)J recombination in vivo and in vitro.
Benoit Roch +6 more
doaj +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
A Physical Theory of the Competition that Allows HIV to Escape from the Immune System [PDF]
, 2006 Competition within the immune system may degrade immune control of viral infections. We formalize the evolution that occurs in both HIV-1 and the immune system quasispecies. Inclusion of competition in the immune system leads to a novel balance between the immune response and HIV-1, in which the eventual outcome is HIV-1 escape rather than control. The
arxiv +1 more source
Frontiers in Immunology, 2022 Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC ...
María Jesús García-León +7 more
doaj +1 more source
Nutrition and the Immune System: A Complicated Tango
Nutrients, 2020 Enthusiasm exists for the potential of diet to impact the immune system, prevent disease and its therapeutic potential. Herein, we describe the challenge to nutrition scientists in defining this relationship through case studies of diets and nutrients in
C. Venter +3 more
semanticscholar +1 more source