Results 1 to 10 of about 3,749,228 (399)

Prion Disease and the Innate Immune System [PDF]

Viruses, 2012
Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious ...
Akira, Ansel, Aucouturier, Baker, Baker, Baker, Barry Bradford, Bartz, Beaulieu, Beekes, Bergtold, Bessen, Blanquet-Grossard, Bruce, Bueler, Burwinkel, Chesebro, Colten, Colten, Cordier-Dirikoc, Cordier-Dirikoc, Cunningham, de Almeida, Dieu, Erblich, Flores-Langarica, Ford, Fraser, Fraser, Fritz, Fu, Gilch, Glaysher, Hamilton, Heppner, Hosszu, Houston, Hunter, Jonjić, Kim, Kimberlin, Kimberlin, Klein, Klein, Kopacek, Kujala, Le, Le, Levavasseur, Li, Liu, Loeuillet, Lu, Luhr, Luhr, Lunnon, Mabbott, Mabbott, Manson, Marella, Marijanovic, Martinez del Hoyo, Mathiason, McCulloch, McCutcheon, Miragliotta, Mitchell, Mohan, Mok, Moore, Neil Mabbott, Oldstone, Opalinska, Paquet, Parkin, Piercey Åkesson, Prinz, Prinz, Prinz, Prusiner, Raymond, Raymond, Raymond, Rescigno, Riemer, Riemer, Riemer, Robertson, Rosicarelli, Rybner, Rybner-Barnier, Saba, Sassa, Schwaeble, Sein, Sethi, Shanas, Silver, Teh, Thackray, Uraki, Uraki, Veerhuis, Walsh, Wang, Wathne, Williams, Xiang, Yadavalli, Yanamadala, Zabel   +110 more
core   +7 more sources

Immune System and Chronic Diseases [PDF]

Journal of Immunology Research, 2017
Margarete Dulce Bagatini, Andréia Machado Cardoso, Alessandra Antunes dos Santos, Fabiano Barbosa Carvalho   +3 more
doaj   +3 more sources

Research progress on Hippo signaling pathway effector molecules in rheumatic immune system diseases. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Gao J, Pi C, Pan J, Zhou W.
europepmc   +3 more sources

Immune System and Chronic Diseases 2018 [PDF]

Journal of Immunology Research, 2018
Margarete Dulce Bagatini, Andréia Machado Cardoso, Cristina Ruedell Reschke, Fabiano Barbosa Carvalho   +3 more
doaj   +3 more sources

Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways

Scientific Data, 2022
Measurement(s) molecules per cell Technology Type(s) nanoflow high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry Sample Characteristic - Organism Mus ...
Nathan P. Manes, Jessica M. Calzola, Pauline R. Kaplan, Iain D. C. Fraser, Ronald N. Germain, Martin Meier-Schellersheim, Aleksandra Nita-Lazar   +6 more
doaj   +1 more source

SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain

Communications Biology, 2023
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions.
Jiansheng Jiang, Christopher T. Boughter, Javeed Ahmad, Kannan Natarajan, Lisa F. Boyd, Martin Meier-Schellersheim, David H. Margulies   +6 more
doaj   +1 more source

Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages

Scientific Reports, 2023
MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation.
Jiraphorn Issara-Amphorn, Virginie H. Sjoelund, Margery Smelkinson, Sebastian Montalvo, Sung Hwan Yoon, Nathan P. Manes, Aleksandra Nita-Lazar   +6 more
doaj   +1 more source

Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation

Nature Communications, 2022
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan   +11 more
doaj   +1 more source

Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

Cell Reports, 2022
Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John, Anju Singh, Jing Sun, Makheni Jean Pierre, Lulwah Alsalih, Crystal Lipsey, Ziann Traore, Shenavia Balcom-Luker, Clinton J. Bradfield, Jian Song, Tovah E. Markowitz, Margery Smelkinson, Marc Ferrer, Iain D.C. Fraser   +13 more
doaj   +1 more source

OMiCC: An expanded and enhanced platform for meta-analysis of public gene expression data

STAR Protocols, 2022
Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis ...
Candace C. Liu, Yongjian Guo, Kiera L. Vrindten, William W. Lau, Rachel Sparks, John S. Tsang   +5 more
doaj   +1 more source