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Immune System and Chronic Diseases [PDF]

Journal of Immunology Research, 2017
Margarete Dulce Bagatini, Andréia Machado Cardoso, Alessandra Antunes dos Santos, Fabiano Barbosa Carvalho   +3 more
doaj   +3 more sources

SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain

Communications Biology, 2023
The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions.
Jiansheng Jiang, Christopher T. Boughter, Javeed Ahmad, Kannan Natarajan, Lisa F. Boyd, Martin Meier-Schellersheim, David H. Margulies   +6 more
doaj   +1 more source

Absolute protein quantitation of the mouse macrophage Toll-like receptor and chemotaxis pathways

Scientific Data, 2022
Measurement(s) molecules per cell Technology Type(s) nanoflow high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry Sample Characteristic - Organism Mus ...
Nathan P. Manes, Jessica M. Calzola, Pauline R. Kaplan, Iain D. C. Fraser, Ronald N. Germain, Martin Meier-Schellersheim, Aleksandra Nita-Lazar   +6 more
doaj   +1 more source

Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages

Scientific Reports, 2023
MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation.
Jiraphorn Issara-Amphorn, Virginie H. Sjoelund, Margery Smelkinson, Sebastian Montalvo, Sung Hwan Yoon, Nathan P. Manes, Aleksandra Nita-Lazar   +6 more
doaj   +1 more source

Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation

Nature Communications, 2022
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan   +11 more
doaj   +1 more source

Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

Cell Reports, 2022
Summary: Biologically active small molecules can impart modulatory effects, in some cases providing extended long-term memory. In a screen of biologically active small molecules for regulators of tumor necrosis factor (TNF) induction, we identify several
Sinu P. John, Anju Singh, Jing Sun, Makheni Jean Pierre, Lulwah Alsalih, Crystal Lipsey, Ziann Traore, Shenavia Balcom-Luker, Clinton J. Bradfield, Jian Song, Tovah E. Markowitz, Margery Smelkinson, Marc Ferrer, Iain D.C. Fraser   +13 more
doaj   +1 more source

OMiCC: An expanded and enhanced platform for meta-analysis of public gene expression data

STAR Protocols, 2022
Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis ...
Candace C. Liu, Yongjian Guo, Kiera L. Vrindten, William W. Lau, Rachel Sparks, John S. Tsang   +5 more
doaj   +1 more source

Immune System Response in Alzheimer's Disease [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1989
ABSTRACT:Involvement of the immune system in the pathogenesis of Alzheimer's disease was demonstrated in two ways: by the attachment of complement proteins to diseased tissue, and by the activation of cells associated with the immune system. Alzheimer brain tissue was stained immunohistochemically by antibodies to components of the classical, but not ...
P L, McGeer, H, Akiyama, S, Itagaki, E G, McGeer   +3 more
openaire   +2 more sources

A new immune disease: systemic hypertension

Clinical Kidney Journal, 2023
ABSTRACT Systemic hypertension is the most common medical comorbidity affecting the adult population globally, with multiple associated outcomes including cerebrovascular diseases, cardiovascular diseases, vascular calcification, chronic kidney disease, metabolic syndrome and mortality.
Sidar Copur, Ibrahim B Peltek, Ali Mutlu, Cem Tanriover, Mehmet Kanbay   +4 more
openaire   +2 more sources

Normalizing and denoising protein expression data from droplet-based single cell profiling

Nature Communications, 2022
Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè, Andrew J. Martins, John S. Tsang   +2 more
doaj   +1 more source