Results 11 to 20 of about 3,483,015 (354)
Sequence Space Localization in the Immune System Response to Vaccination and Disease [PDF]
Phys. Rev. Lett. 91 (2003) 068101, 2003 We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can \emph{increase} susceptibility to future exposures to the same disease, is explained as stemming from localization of the immune system
Michael W. Deem, Ha Youn Lee
arxiv +3 more sources
The Innate Immune System in Alzheimer’s Disease [PDF]
International Journal of Cell Biology, 2013 Alzheimer’s disease (AD) is the leading cause for dementia in the world. It is characterized by two biochemically distinct types of protein aggregates: amyloidβ(Aβ) peptide in the forms of parenchymal amyloid plaques and congophilic amyloid angiopathy (CAA) and aggregated tau protein in the form of intraneuronal neurofibrillary tangles (NFT).
Allal Boutajangout, Thomas Wisniewski
openaire +6 more sources
Overview of the Immune System and Immunodeficiency Diseases
Veterinary Clinics of North America: Small Animal Practice, 1994 The principal role of the immune system is the protection of the host against invasion by infectious disease agents and other substances considered foreign to the host. The term "immunity" refers to all the mechanisms that the body uses to protect itself against environmental antigens. This article gives an overview of the immune system and its defense
Peter J. Felsburg
openaire +4 more sources
The Role of the Immune System in Huntington’s Disease [PDF]
Clinical and Developmental Immunology, 2013 Huntington’s disease (HD) is characterized by a progressive course of disease until death 15–20 years after the first symptoms occur and is caused by a mutation with expanded CAG repeats in the huntingtin (htt) protein. Mutant htt (mhtt) in the striatum is assumed to be the main reason for neurodegeneration.
Gisa Ellrichmann +3 more
openaire +6 more sources
Hodgkin Disease and the Role of the Immune System [PDF]
Pediatric Hematology and Oncology, 2011 Hodgkin disease (HD) is a malignancy of primarily B lymphocytes that has the unique ability to cause immunodeficiency, as well as provide immune evasion mechanisms to avoid self-destruction. In this review, the authors discuss Hodgkin disease, its association with Epstein-Barr virus (EBV), the immune deficiency caused by HD, and tumor immune evasion ...
Catherine M. Bollard +2 more
openaire +4 more sources
Multiple Sclerosis is Not a Disease of the Immune System
The Quarterly Review of Biology, 2011 Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations.
Angélique Corthals
openaire +5 more sources
Small and Long Regulatory RNAs in the Immune System and Immune Diseases [PDF]
Frontiers in Immunology, 2014 Cellular differentiation is regulated on the level of gene expression, and it is known that dysregulation of gene expression can lead to deficiencies in differentiation that contribute to a variety of diseases, particularly of the immune system. Until recently, it was thought that the dysregulation was governed by changes in the binding or activity of ...
Anna Stachurska +3 more
openaire +6 more sources
The adaptive immune system in diseases of the central nervous system [PDF]
Journal of Clinical Investigation, 2012 Tissues of the CNS, such as the brain, optic nerves, and spinal cord, may be affected by a range of insults including genetic, autoimmune, infectious, or neurodegenerative diseases and cancer. The immune system is involved in the pathogenesis of many of these, either by causing tissue damage or alternatively by responding to disease and contributing to
Wraith, David C, Nicholson, Lindsay B
openaire +4 more sources
Pathogenesis of Bone Diseases: The Role of Immune System [PDF]
Journal of Immunology Research, 2015 Bone is a metabolically active tissue that undergoes continuous remodeling by two sequential events, bone formation and resorption. These events are strongly linked and tightly regulated to maintain skeletal homeostasis. The bone cells responsible for the dual events include the bone-resorbing cells, the osteoclasts, arising from monocyte-macrophage ...
Brunetti, Giacomina +3 more
openaire +8 more sources
Immune System and Chronic Diseases [PDF]
Journal of Immunology Research, 2017 Margarete Dulce Bagatini +3 more
openaire +3 more sources