Results 31 to 40 of about 3,483,015 (354)
Scientific Reports, 2023 MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein expressed in many cell types, including macrophages. MARCKS is functionally implicated in cell adhesion, phagocytosis, and inflammation.
Jiraphorn Issara-Amphorn +6 more
doaj +1 more source
Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation
Nature Communications, 2022 The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide ...
Jiansheng Jiang +11 more
doaj +1 more source
The Road Less Taken: Less Appreciated Pathways for Manipulating CD8+ T Cell Exhaustion
Frontiers in Immunology, 2022 Exhausted CD8+ T (Tex) cells are a distinct cell population that arise during persistent antigen exposure in the context of chronic infections and cancers.
Andrea C. Pichler +3 more
doaj +1 more source
Normalizing and denoising protein expression data from droplet-based single cell profiling
Nature Communications, 2022 Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Matthew P. Mulè +2 more
doaj +1 more source
eLife, 2023 T cells are critically important components of the adaptive immune system primarily responsible for identifying and responding to pathogenic challenges.
Christopher T Boughter +1 more
doaj +1 more source
Thirty years of resistance: Zig-zag through the plant immune system
The Plant Cell, 2022 Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response system. The first plant Resistance (R) gene was cloned in 1992 . Since then,
Bruno Pok Man Ngou +2 more
semanticscholar +1 more source
Molecular Mechanisms of the Toll-Like Receptor, STING, MAVS, Inflammasome, and Interferon Pathways
mSystems, 2021 Pattern recognition receptors (PRRs) form the front line of defense against pathogens. Many of the molecular mechanisms that facilitate PRR signaling have been characterized in detail, which is critical for the development of accurate PRR pathway models ...
Nathan P. Manes, Aleksandra Nita-Lazar
doaj +1 more source
Prion Disease and the Innate Immune System [PDF]
Viruses, 2012 Prion diseases or transmissible spongiform encephalopathies are a unique category of infectious protein-misfolding neurodegenerative disorders. Hypothesized to be caused by misfolding of the cellular prion protein these disorders possess an infectious quality that thrives in immune-competent hosts.
Barry Bradford, Neil Mabbott
openaire +5 more sources
mSystems, 2021 Macrophages and monocytes are innate immune cells playing an important role in orchestrating the initial innate immune response to bacterial infection and the tissue damage.
Orna Ernst +11 more
doaj +1 more source
Nutrients, 2021 The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide.
C. García-Montero +16 more
semanticscholar +1 more source