Results 91 to 100 of about 2,034,935 (392)
Therapeutic Advances in Hematology, 2021 The treatment of immune thrombocytopenia (ITP) in adults has evolved rapidly over the past decade. The second-generation thrombopoietin receptor agonists (TPO-RAs), romiplostim, eltrombopag, and avatrombopag are approved for the treatment of chronic ITP ...
Nikki Agarwal, Ankit Mangla
semanticscholar +1 more source
Discussion required for correct interpretation [PDF]
, 2006 Thank you for the opportunity to comment on the editorial by Romero and colleagues [1], which raises a number of important and interesting questions.
Aguan +10 more
core +3 more sources
Advanced Science, EarlyView.A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun +23 more
wiley +1 more source
COVID‐19‐associated immune thrombocytopenia
British Journal of Haematology, 2020 Thrombocytopenia is a risk factor for increased morbidity and mortality in patients with the new severe acute respiratory syndrome corona virus, SARS-CoV-2 infection (COVID-19 infection).1 Thrombocytopenia in COVID-19 patients may be caused by ...
G. Bomhof +6 more
semanticscholar +1 more source
An Update on Pediatric Immune Thrombocytopenia (ITP): Differentiating Primary ITP, IPD, and PID.
Blood, 2021 Immune thrombocytopenia (ITP) is the most common acquired thrombocytopenia in children and is caused by both immune-mediated decreased platelet production and increased platelet destruction. In the absence of a diagnostic test, ITP must be differentiated
R. Grace, Michele P. Lambert
semanticscholar +1 more source
Physician decision making in selection of second-line treatments in immune thrombocytopenia in children. [PDF]
, 2018 Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder which presents with isolated thrombocytopenia and risk of hemorrhage. While most children with ITP promptly recover with or without drug therapy, ITP is persistent or chronic in ...
Bennett, Carolyn M. +23 more
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Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source
Immune Thrombocytopenia in Antiphospholipid Syndrome: Is It Primary or Secondary?
Biomedicines, 2021 Antiphospholipid syndrome (APS) is frequently associated with thrombocytopenia, in most cases mild and in the absence of major bleedings. In some patients with a confirmed APS diagnosis, secondary immune thrombocytopenia (ITP) may lead to severe ...
R. Tomasello +6 more
semanticscholar +1 more source
Immune-Mediated Thrombocytopenia
Veterinary Quarterly, 1998 • Immune-mediated thrombocytopenia (IMTP) is rare and poorly documented in the cat (in contrast to the dog). • Cause: most cases are likely to be secondary (particularly to FeLV infection and associated neoplasia) rather than primary autoimmune thrombocytopenia (AITP). • Signs: vague eg anorexia, lethargy.
openaire +2 more sources
Advanced Science, EarlyView.This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao +13 more
wiley +1 more source