Results 191 to 200 of about 288,299 (272)

Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans. [PDF]

Nat Commun
Cildir G, Aba U, Pehlivan D, Tvorogov D, Warnock NI, Ipsir C, Arik E, Kok CH, Bozkurt C, Tekeoglu S, Inal G, Cesur M, Kucukosmanoglu E, Karahan I, Savas B, Balci D, Yaman A, Demirbaş ND, Tezcan I, Haskologlu S, Dogu F, Ikinciogulları A, Keskin O, Tumes DJ, Erman B.   +24 more
europepmc   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Pregnancy-related factors induce immune tolerance through regulation of sCD83 release. [PDF]

Front Immunol
Krupa P, Wein H, Zemmrich LS, Zygmunt M, Muzzio DO.   +4 more
europepmc   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Advances in Immune Tolerance Induction in Enzyme Replacement Therapy. [PDF]

Paediatr Drugs
İnci A, Ezgü FS, Tümer L.
europepmc   +1 more source

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions

Advanced Science, EarlyView.
Icaritin demonstrates broad antitumor effects by inhibiting colorectal cancer (CRC) cell proliferation, migration, invasion, and causing cell cycle arrest. It induces apoptosis by repressing autophagic flux through disrupting HSP90‐TXNDC9 interactions.
Dan He, Siliang Chen, Xiaoyun Wang, Xiang Wen, Changyang Gong, Lei Liu, Gu He   +6 more
wiley   +1 more source

Arbutin overcomes tumor immune tolerance by inhibiting tumor programmed cell death-ligand 1 expression. [PDF]

Int J Med Sci
Liu CH, Weng JR, Wu LH, Song RY, Huang MD, Wu XH, Wang CC, Lee CH.   +7 more
europepmc   +1 more source

A Compound Screen Based on Isogenic hESC‐Derived β Cell Reveals an Inhibitor Targeting ZnT8‐Mediated Zinc Transportation to Protect Pancreatic β Cell from Stress‐Induced Cell Death

Advanced Science, EarlyView.
Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. The study demonstrates that WFS1–ZnT8–zinc axis regulates vicious cycle of zinc transportation and cellular stress in pancreatic β cell. Based on that, the study applies a strategy for compound screening targeting ZnT8 based on human models, and identifies anisomycin, as a ...
Rui Hu, Qing Ma, Yunhui Kong, Zhaoyue Wang, Minglu Xu, Xiangyi Chen, Yajuan Su, Tinghui Xiao, Qing He, Xuan Wang, Wenjun Xu, Yiling Yang, Xushu Wang, Xiaobo Li, Yanfang Liu, Shuangshuang Chen, Rui Zhao, Meng Guo, Gaowei Wang, Weida Li   +19 more
wiley   +1 more source

TCA metabolism regulates DNA hypermethylation in LPS and <i>Mycobacterium tuberculosis</i>-induced immune tolerance. [PDF]

Proc Natl Acad Sci U S A
Abhimanyu, Longlax SC, Nishiguchi T, Ladki M, Sheikh D, Martinez AL, Mace EM, Grimm SL, Caldwell T, Portillo Varela A, Sekhar RV, Mandalakas AM, Mlotshwa M, Ginidza S, Cirillo JD, Wallis RS, Netea MG, van Crevel R, Coarfa C, DiNardo AR.   +19 more
europepmc   +1 more source