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Immunity and tolerance to Aspergillus fumigatus.
Novartis Foundation symposium, 2006The inherent resistance to diseases caused by Aspergillus fumigatus suggests the occurrence of regulatory mechanisms that provide the host with adequate defence without necessarily eliminating the fungus or causing unacceptable levels of host damage. Efficient responses to the fungus require different mechanisms of immunity.
MONTAGNOLI, Claudia +8 more
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Tolerance and Immunity in the Intestinal Immune System
Critical Reviews™ in Immunology, 2000The intestinal immune system must guard the body against invasion by pathogens while avoiding a response to the many potential antigens present in food. In the absence of the inflammatory stimuli necessary to elicit an immune response, oral administration of soluble protein antigens induces antigen-specific systemic nonresponsiveness.
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Tolerance and immune regulation
Immunology Today, 1991Understanding of both the phenomenon of immunological tolerance and the mechanisms by which it is achieved is rapidly advancing, as was evident from a recent meeting. This report summarizes key developments in both T- and B-cell biology.
Robey, Ellen, Urbain, Jacques
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Mechanisms of Immune Tolerance to Allergens
2012In allergic diseases, immune responses are induced by normally well-tolerated allergens, which result in chronic inflammation characterized by antibody secretion and T cell activation. For almost 100 years, allergen-specific immunotherapy (allergen-SIT) has been the potentially curative and antigen-specific method for the treatment of allergic diseases.
Hiroyuki Fujita +5 more
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Mucosal immunity and tolerance in the elderly
Mechanisms of Ageing and Development, 2004Age-associated dysregulation of the immune system of the gastrointestinal (GI) tract has been well documented for both secretory (S)-IgA immunity and oral tolerance. Thus, impaired antigen-specific Ab responses in aged animals and the elderly have been reported.
Jerry R. McGhee, Kohtaro Fujihashi
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The Liver and Immune Tolerance
2013As the largest solid organ in the body, the liver plays a critical role in metabolism and detoxification. Recently, emerging evidence suggests that the liver is an immunological organ with unique properties of predominant innate immunity and immune tolerance.
Zhe-Xiong Lian +3 more
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Restoration of Immune Tolerance
2000The function of the immune response is to protect an organism from foreign material by first recognizing the material as foreign and then activating a cascade of events that leads to its removal. To perform this function without damaging the host, the immune system must distinguish between self and nonself, and target removal mechanisms only toward ...
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Immunity and tolerance: A unified concept
Cellular Immunology, 1971Immunity and Tolerance were first described and studied using living cells as antigen. This is not surprising since living cells constitute (as the basis for “self”) the main unit to be preserved as well as the main threat as potential parasitic invaders to complex living organisms.
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Bile acids for immune tolerance
Science Signaling, 2021The bacterial bile acid metabolite isoalloLCA stimulates the differentiation of T reg cells.
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Immune Tolerance in Breast Cancer
Breast Disease, 2004In spite of the demonstrated coexistence of tumor-associated rejection antigens expressed by breast tumors along with T cells that are capable of recognize them, breast cancers arises in immunocompetent hosts, outmaneuver immune recognition and ultimately progress to widely disseminated disease.
Dmitry I. Gabrilovich +2 more
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