Results 51 to 60 of about 2,852,359 (355)

Mechanisms of immunological tolerance in central nervous system inflammatory demyelination. [PDF]

, 2015
Multiple sclerosis is a complex autoimmune disease of the central nervous system that results in a disruption of the balance between pro-inflammatory and anti-inflammatory signals in the immune system.
Anderton, Ando, Andres, Apetoh, Astier, Awasthi, Bacchetta, Bacchetta, Barrat, Batten, Bennett, Borsellino, Brunkow, Cedeno-Laurent, Chen, Chen, Dalla Libera, Darrasse-Jeze, David, Dominguez-Villar, Durelli, El-Behi, Faria, Fitzgerald, Fitzgerald, Fitzgerald, Fletcher, Fontenot, Frisullo, Gagliani, Gandhi, Garin, Getts, Getts, Gregory, Groux, Haak, Haas, Haas, Harrington, Hilliard, Hong, Hori, Huan, Huang, Huber, Hunter, Iellem, Ilarregui, Jiang, Joller, Kipnis, Kohm, Komiyama, Kopcow, Korn, Korn, Korporal, Kroenke, Kuniyasu, Langrish, Laouar, Leech, Leonard, Li, Liblau, Lutterotti, Magnani, Mariathasan, Markiewicz, Martinez-Forero, Mascanfroni, McGeachy, Mehling, Miller, Mosmann, Muls, Noseworthy, O'Connor, Ohnmacht, Peng, Pflanz, Pflanz, Pitkanen, Pot, Pot, Pot, Rabinovich, Ramgolam, Ratts, Read, Rostami, Rovetto, Russell, Sakaguchi, Secor, Segal, Sela, Smith, Stephens, Stumhofer, Sundstedt, Takahashi, Takeda, Tigno-Aranjuez, Toscano, Turley, Tzartos, Uyttenhove, Veen, Venken, Venken, Vieira, Viglietta, Villarino, Voskuhl, Wang, Wang, Weiner, Wildbaum, Wildin, Xu, Yamaguchi, Yamazaki, Yang, Yang, Zhang, Zhang, Zhang, Zhang   +129 more
core   +2 more sources

Alloactivation of Naïve CD4+CD8−CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction

Frontiers in Immunology, 2019
Therapy with alloantigen-specific CD4+CD25+ T regulatory cells (Treg) for induction of transplant tolerance is desirable, as naïve thymic Treg (tTreg) are not alloantigen-specific and are weak suppressor cells.
Nirupama D. Verma, Catherine M. Robinson, Nicole Carter, Paul Wilcox, Giang T. Tran, Chaunmin Wang, Alexandra Sharland, Masaru Nomura, Karren M. Plain, G. Alexander Bishop, Suzanne J. Hodgkinson, Bruce M. Hall   +11 more
doaj   +1 more source

Regulation of Tumor Immunity by Tumor/Dendritic Cell Fusions [PDF]

, 2010
The goal of cancer vaccines is to induce antitumor immunity that ultimately will reduce tumor burden in tumor environment. Several strategies involving dendritic cells- (DCs)- based vaccine incorporating different tumor-associated antigens to induce ...
Gong, Jianlin, Hara, Eiichi, Homma, Sadamu, Ito, Masaki, Koido, Shigeo, Komita, Hideo, Nagasaki, Eijiro, Namiki, Yoshihisa, Ohkusa, Toshifumi, Tajiri, Hisao, Takahara, Akitaka   +10 more
core   +4 more sources

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source

CD4+CD25+ T regulatory cells in renal transplantation

Frontiers in Immunology, 2022
The immune response to an allograft activates lymphocytes with the capacity to cause rejection. Activation of CD4+CD25+Foxp3+T regulatory cells (Treg) can down-regulate allograft rejection and can induce immune tolerance to the allograft. Treg represent &
Jason Cheung, Beata Zahorowska, Michael Suranyi, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Jason Diep, Stephen T. Spicer, Stephen T. Spicer, Nirupama D. Verma, Nirupama D. Verma, Suzanne J. Hodgkinson, Suzanne J. Hodgkinson, Bruce M. Hall, Bruce M. Hall, Bruce M. Hall   +15 more
doaj   +1 more source

Dexamethasone Preconditioning Improves the Response of Collagen-Induced Arthritis to Treatment with Short-Term Lipopolysaccharide-Stimulated Collagen-Loaded Dendritic Cells

Clinical and Developmental Immunology, 2013
Background. Pharmacologically modulated dendritic cells (DCs) have been shown to restore tolerance in type II collagen-(CII-) induced arthritis (CIA). We examined the effect of dexamethasone (DXM) administration as a preconditioning agent, followed by an
Corina Peña, David Gárate, Juan Contreras-Levicoy, Octavio Aravena, Diego Catalán, Juan C. Aguillón   +5 more
doaj   +1 more source

Adaptive immunity in cancer immunology and therapeutics. [PDF]

, 2014
Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,
Lockley, M, Spurrell, EL
core   +2 more sources

Oral tolerance to cancer can be abrogated by T regulatory cell inhibition [PDF]

, 2014
Oral administration of tumour cells induces an immune hypo-responsiveness known as oral tolerance. We have previously shown that oral tolerance to a cancer is tumour antigen specific, non-cross-reactive and confers a tumour growth advantage.
A Micheli, AB Castro-Junior, AM Faria, Barbara-ann Guinn, DJ Needham, Garrett Casey, Gerald C. O'Sullivan, H Nishikawa, HL Weiner, HL Weiner, HY Wang, J Larkin, J Murphy, John O. Larkin, L Chen, Maria C. Whelan, Mark Tangney, MC Whelan, MG O'Brien, P Castro-Sanchez, RB Nussenblatt, SA Collins, SD Khare, V Boncheva, Valli De Re, X Wang, Y Chen, Y Zhang   +27 more
core   +3 more sources

Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway

Nature Communications
Commensal bacteria generate immensely diverse active metabolites to maintain gut homeostasis, however their fundamental role in establishing an immunotolerogenic microenvironment in the intestinal tract remains obscure.
Yanan Zhang, Shuyu Tu, Xingwei Ji, Jianan Wu, Jinxin Meng, Jinsong Gao, Xian Shao, Shuai Shi, Gan Wang, Jingjing Qiu, Zhuobiao Zhang, Chengang Hua, Ziyi Zhang, Shuxian Chen, Li Zhang, S. Zhu   +15 more
semanticscholar   +1 more source

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance [PDF]

, 2014
Current treatments to control pathological or unwanted immune responses often use broadly immunosuppressive drugs. New approaches to induce antigen-specific immunological tolerance that control both cellular and humoral immune responses are desirable ...
Altreuter, David H., Browning, Erica A., Farokhzad, Omid C., Ferrari, Joseph D., Griset, Aaron P., Johnston, Lloyd P. M., Kishimoto, Takashi Kei, Kolte, Pallavi N., LaMothe, Robert A., Langer, Robert S, Maldonado, Roberto A., O'Neil, Conlin P., Rossi, Robert J., Scott, David W., von Andrian, Ulrich H., Zhang, Ai-Hong   +15 more
core   +1 more source