Results 51 to 60 of about 792,578 (312)

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Trial watch: anticancer vaccination with dendritic cells

OncoImmunology
Dendritic cells (DCs) are critical players at the intersection of innate and adaptive immunity, making them ideal candidates for anticancer vaccine development.
Francisca Borges, Raquel S. Laureano, Isaure Vanmeerbeek, Jenny Sprooten, Octavie Demeulenaere, Jannes Govaerts, Lisa Kinget, Saurabh Saraswat, Benoit Beuselinck, Steven De Vleeschouwer, Paul Clement, Frederik De Smet, Rüdiger V. Sorg, Angeliki Datsi, Nathalie Vigneron, Stefan Naulaerts, Abhishek D. Garg   +16 more
doaj   +1 more source

Abnormalities in soluble CD147 / MMPs / TIMPs axis in Ankylosing Spondylitis patients with and without a history of Acute Anterior Uveitis / Anomalii ale axei CD147 solubil / MMPs / TIMPs la pacienții cu spondilită anchilozantă cu sau fără uveită acută anterioară

Romanian Journal of Laboratory Medicine, 2014
Spondilita Anchilozantă (SA) este prototipul formei axiale a spondiloartritelor. În pofida studiilor extinse, sunt încă incomplet înțelese mecansimele complexe legate de procesele celulare și moleculare anormale din SA.
Mitulescu Traian Costin, Voinea Liliana Mary, Predeteanu Denisa, Banica Leontina Mirela, Stavaru Crina, Matache Cristiana   +5 more
doaj   +1 more source

Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis

Frontiers in Immunology, 2019
Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the host innate immune response in pathogenesis ...
Catherine F. Hatton, Christopher J. A. Duncan, Christopher J. A. Duncan   +2 more
doaj   +1 more source

Integrated antibody and cellular immunity monitoring are required for assessment of the long term protection that will be essential for effective next generation vaccine development

Frontiers in Immunology, 2023
The COVID pandemic exposed the critical role T cells play in initial immunity, the establishment and maintenance of long term protection, and of durable responsiveness against novel viral variants.
Eustache Paramithiotis, Christophe Varaklis, Stephane Pillet, Shahin Shafiani, Mary Pat Lancelotta, Steve Steinhubl, Steve Steinhubl, Scott Sugden, Matt Clutter, Damien Montamat-Sicotte, Todd Chermak, Stephanie Y. Crawford, Bruce L. Lambert, John Mattison, Robert L. Murphy   +14 more
doaj   +1 more source

Critical parameters in dynamic network modeling of sepsis [PDF]

arXiv, 2022
In this work, we propose a dynamical systems perspective on the modeling of sepsis and its organ-damaging consequences. We develop a functional two-layer network model for sepsis based upon the interaction of parenchymal cells and immune cells via cytokines, and the coevolutionary dynamics of parenchymal, immune cells, and cytokines.
arxiv  

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Growing old with the immune system: a study of immunosenescence in the zebra finch (Taeniopygia guttata) [PDF]

, 2011
Immunosenescence has not received much attention in birds and the few existing studies indicate that the occurrence of immunosenescence and/or its extent may differ between species.
AP Møller, B Grubeck-Loebenstein, BI Tieleman, BI Tieleman, C Franceschi, Claus Bech, CM Lessells, CR Gomez, D Holmes, DA Roff, DJ Holmes, DM Buehler, Elin Noreen, ET Lavoie, F Davison, G Coster De, G Pawelec, GA Lozano, I Folstad, J Martinez, J Martinez-Padilla, JE Smits, JL Tella, K Norris, KD Matson, KD Matson, L Malaguarnera, LB Martin, LL Berzins, M Cichon, M Cichon, M Tobler, MA Blasco, ME Viney, MF Haussmann, MG Palacios, ML Roberts, N Goto, N Saino, N Saino, NH Son, P Monaghan, RA Goldsby, RA Miller, RA Zann, RB Effros, RL Trivers, S Braude, S Verhulst, SC Stearns, Sophie Bourgeon, TH Clutton-Brock, TS Johnsen, V Apanius, V Apanius   +54 more
core   +2 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway

Frontiers in Pharmacology
Gallic acid (GA), a natural organic phenolic compound, is an abundant plant food bioactive substance present in many medicinal herbs. GA has anti-oxidative, anti-inflammatory and anticancer activities on multiple metabolic disorders.
Jiahao Qiu, Jiahao Qiu, Lihong Fu, Yan Xue, Yan Xue, Yilan Yang, Fengjie Qiao, Wanchun Zhu, Yating Gao, Miao Fang, Yufei Liu, Zhujun Gao, Yunfeng Guan, Yunfeng Guan, Yueqiu Gao, Yueqiu Gao, Yueqiu Gao, Xin Zhang, Zhi Shang, Zhi Shang, Zhi Shang   +20 more
doaj   +1 more source