Results 51 to 60 of about 562,820 (312)

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Brinkman, Fiona S. L., Laird, Matthew R, Amir K. Foroushani, David J. Lynn, Anastasia Sribnaia, Lynn, David J, Lo, Raymond, Raymond Lo, Foroushani, Amir K., Winsor, Geoffrey L, Breuer, Karin, Chen, Carol, Robert E. W. Hancock, Matthew R. Laird, Carol Chen, Geoffrey L. Winsor, Sribnaia, Anastasia, Hancock, Robert E.W., Karin Breuer, Fiona S. L. Brinkman   +19 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Research trends of mitochondrial dysfunction in hepatic fibrosis: a bibliometric analysis

Frontiers in Physiology
BackgroundHepatic fibrosis is a progressive pathological process driven by multiple chronic liver injury factors. Increasing evidence highlights that mitochondrial dysfunction serves as a pivotal mechanism in the onset and progression of hepatic fibrosis.
Xingtao Jin, Xingtao Jin, Yanlu Ma, Yanlu Ma, Yiqiang Tang, Yiqiang Tang, Fengjie Qiao, Fengjie Qiao, Tong Xiao, Tong Xiao, Yu Cui, Yu Cui, Man Li, Man Li, Yueqiu Gao, Yueqiu Gao   +15 more
doaj   +1 more source

Integrated antibody and cellular immunity monitoring are required for assessment of the long term protection that will be essential for effective next generation vaccine development

Frontiers in Immunology, 2023
The COVID pandemic exposed the critical role T cells play in initial immunity, the establishment and maintenance of long term protection, and of durable responsiveness against novel viral variants.
Eustache Paramithiotis, Christophe Varaklis, Stephane Pillet, Shahin Shafiani, Mary Pat Lancelotta, Steve Steinhubl, Steve Steinhubl, Scott Sugden, Matt Clutter, Damien Montamat-Sicotte, Todd Chermak, Stephanie Y. Crawford, Bruce L. Lambert, John Mattison, Robert L. Murphy   +14 more
doaj   +1 more source

In-vitro demonstration of cell-mediated immunity to vaccinia virus in man [PDF]

, 1975
Cell mediated immunity to vaccinia virus in man was studied by lymphocyte transformation. Vaccinia antigen, propagated on BHK-21 and Vero cells, could be used successfully for in-vitro testing after partial purification as well as crude infectious ...
Koszinowski, Ulrich H., Thomssen, R., Volkmann, B.   +2 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cellular immunity in healthy volunteers treated with an octavalent conjugate Pseudomonas aeruginosa vaccine

, 2005
Humoral immunity in response to an octavalent O-polysaccharide-toxin A conjugate Pseudomonas aeruginosa vaccine is well studied, and a phase III clinical study in cystic fibrosis (CF) patients is currently ongoing.
H Chtioui, A W Zuercher, D Bosse, Ulrich, M, S Jampen, Chtioui, H, Lang, A B, Zuercher, A W, Lauterburg, B H, A B Lang, Imboden, M A, M Ulrich, M A Imboden, Bosse, D, Jampen, S, B H Lauterburg   +15 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Determination of HMGB1 in hepatitis B virus-related acute-on-chronic liver failure patients with acute kidney injury: Early prediction and prognostic implications

Frontiers in Pharmacology, 2023
Background: Acute kidney injury (AKI) is a frequent complication in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and is associated with high rates of mortality. We aimed to estimate serum high mobility group protein 1
Yu Liu, Yu Liu, Wei Yuan, Miao Fang, Hongying Guo, Xin Zhang, Xue Mei, Yuyi Zhang, Longshan Ji, Yating Gao, Jiefei Wang, Zhiping Qian, Man Li, Yueqiu Gao, Yueqiu Gao   +14 more
doaj   +1 more source

Immunity and the emergence of individuality [PDF]

, 2013
Since (Buss 1987), it has become clear that individuality is not to be considered as a given, but rather as something which needs to be explained. How has individuality emerged through evolution, and how has it subsequently been maintained? In particular,
Pradeu, Thomas
core