Results 31 to 40 of about 164,492 (254)

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

Cell Reports, 2018
Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown.
Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Oliver Ohlenschläger, Jordan D. Dimitrov, Hugo Mouquet   +14 more
doaj   +1 more source

Humoral Immunity to Hantavirus Infection

mSphere, 2020
Hantaviruses are zoonotic pathogens found in parts of Europe, Asia, South America, and North America, which can cause renal and respiratory failure with fatality rates up to 40%. There are currently no FDA-approved vaccines or therapeutics for hantavirus-
Taylor B. Engdahl, James E. Crowe
doaj   +3 more sources

A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways in Drosophila Immunity

Frontiers in Immunology, 2020
Innate immunity is an evolutionarily conserved host defense system against infections. The fruit fly Drosophila relies solely on innate immunity for infection defense, and the conservation of innate immunity makes Drosophila an ideal model for ...
Shinzo Iwashita, Hiroaki Suzuki, Akira Goto, Akira Goto, Tomohito Oyama, Hirotaka Kanoh, Takayuki Kuraishi, Takayuki Kuraishi, Naoyuki Fuse, Tamaki Yano, Yoshiteru Oshima, Julian A. T. Dow, Shireen-Anne Davies, Shoichiro Kurata   +13 more
doaj   +1 more source

PTX3 is expressed in terminal lymphatics and shapes their organization and function

Frontiers in Immunology
IntroductionThe lymphatic system is a multifaceted regulator of tissue homeostasis and an integral part of immune responses. Previous studies had shown that subsets of lymphatic endothelial cells (LEC) express PTX3, an essential component of humoral ...
Andrea Doni, Marina Sironi, Annalisa Del Prete, Annalisa Del Prete, Fabio Pasqualini, Sonia Valentino, Ivan Cuccovillo, Raffaella Parente, Michela Calvi, Antonella Tosoni, Gianluca Vago, Manuela Nebuloni, Cecilia Garlanda, Cecilia Garlanda, Annunciata Vecchi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani   +18 more
doaj   +1 more source

Interferon Status and Choice of Interferons Inducers in Frequently Ill Children

Детские инфекции (Москва), 2016
Literature data on the study of interferon status in children. Own results of the survey group of frequently ill children (FIC) have shown insufficient production of IFN alpha and gamma-IFN, humoral immunity. It was revealed that 66% of the group FIC has
M. S. Savenkovа, O. V. Karashtinа, M. B. Shabat, G. N. Kraseva, N. A. Abramova, T. E. Kraseva   +5 more
doaj   +1 more source

Moderate to severe SARS-CoV-2 infection primes vaccine-induced immunity more effectively than asymptomatic or mild infection

npj Vaccines, 2022
Hybrid immunity induced by vaccination following recovery from SARS-CoV-2 infection is more robust than immunity induced by either infection or vaccination alone.
Kayla A. Holder, Danielle P. Ings, Debbie O. A. Harnum, Rodney S. Russell, Michael D. Grant   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Timing of Assessment of Humoral and Cell-Mediated Immunity after Influenza Vaccination

Vaccines
Assessment of the immune response to influenza vaccines should include an assessment of both humoral and cell-mediated immunity. However, there is a lack of consensus regarding the timing of immunological assessment of humoral and cell-mediated immunity ...
Naruhito Otani, Kazuhiko Nakajima, Kumiko Yamada, Kaori Ishikawa, Kaoru Ichiki, Takashi Ueda, Yoshio Takesue, Takuma Yamamoto, Satoshi Higasa, Susumu Tanimura, Yuta Inai, Toshiomi Okuno   +11 more
doaj   +1 more source