Results 91 to 100 of about 2,138,040 (291)
Innate and adaptive immunity in teleost fish: a review.
, 2018 The immune system of fish is very similar to vertebrates, although there are some important dif - ferences. Fish are free-living organisms from the embryonic stage of life in their aquatic environment.
C. Uribe +3 more
semanticscholar +1 more source
Double-Stranded RNA Sensors and Modulators in Innate Immunity.
Annual Review of Immunology, 2019 Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity.
S. Hur
semanticscholar +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Cell Research, 2015 Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation (OXPHOS), similar to the Warburg effect in tumors.
B. Kelly, L. O’Neill
semanticscholar +1 more source
Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo +11 more
wiley +1 more source
Interferon Lambda Genetics and Biology in Regulation of Viral Control
Frontiers in Immunology, 2017 Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral ...
Emily A. Hemann, Michael Gale, Ram Savan
doaj +1 more source
Innate Lymphoid Cells in Mucosal Immunity
Frontiers in Immunology, 2019 Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells.
S. Panda, M. Colonna
semanticscholar +1 more source
Molecular Oncology, EarlyView.Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley +1 more source
CellsParasitoid elimination in Drosophila melanogaster involves special hemocytes, called lamellocytes, which encapsulate the eggs or larvae of the parasitoid wasps. The capsules are melanized, and metabolites of the melanization reaction may play a potential
Lilla B. Magyar +2 more
doaj +1 more source
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Nature reviews. Immunology, 2021 P. Roy, Marco Orecchioni, K. Ley
semanticscholar +1 more source