Results 81 to 90 of about 738,337 (299)

Development of the Innate Immune Response in NestlingTree Swallows (Tachycineta bicolor) [PDF]

, 2009
The innate immune system provides an immediate, short term, first line of defense from pathogens; its appearance early in development in vertebrates is evidence of its critical importance.
Stambaugh, T.R.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system [PDF]

, 2016
The invertebrate's innate immune system was reported to show some form of adaptive features, termed trained immunity. However, the memory characteristics of innate immune system and the mechanisms behind such phenomena remain unclear.
Baruah, Sri Kartik, Biswas, Priyanka, Bossier, Peter, Norouzitallab, Parisa, Vanrompay, Daisy   +4 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Immunomodulatory Effects and Protection in Sepsis by the Antibiotic Moxifloxacin

Antibiotics
Sepsis is a leading cause of death in Intensive Care Units. Despite its prevalence, sepsis remains insufficiently understood, with no substantial qualitative improvements in its treatment in the past decades.
Tiago R. Velho, Helena Raquel, Nuno Figueiredo, Ana Neves-Costa, Dora Pedroso, Isa Santos, Katharina Willmann, Luís F. Moita   +7 more
doaj   +1 more source

Nutrition, diet and immunosenescence [PDF]

, 2013
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
Agrawal, Agrawal, Akbar, Almanzar, Alonso, Alperovich, Alvarez-Rodriguez, Arunachalam, Azzini, Bates, Bechoua, Belisle, Belisle, Berzins, Blomberg, Bogden, Borrego, Bouwens, Bravo, Buffa, Bunout, Butcher, Calder, Camous, Canaday, Cannizzo, Carluccio, Castle, Cevenini, Chandra, Chatta, Chidrawar, Chung, Ciaramella, Clambey, Clark, Claudio Nicoletti, Colonna-Romano, Corridan, Corsini, Cortes, Cossack, Currier, De La Fuente, De la Fuente, De la Fuente, De Martinis, DelaRosa, DelaRosa, Della Bella, Dell’Agli, Dewan, Di Lorenzo, Dong, Donnini, Dorshkind, Dubey, Duchateau, Dunn-Walters, Effros, Enos, Estruch, Farges, Fateh, Faunce, Fearnley, Feart, Fietta, Flores, Fortes, Fortin, Fortin, Franceschi, Franceschi, Frasca, Frasca, Fulop, Fulop, Fulop, Fulop, Galli, Gao, Gayoso, Gebremichael, Gibson, Gibson, Gill, Gill, Ginaldi, Gomez, Goronzy, Goronzy, Guigoz, Guigoz, Hadziabdic, Hakim, Hamilton-Miller, Haynes, Haynes, Haynes, Herndler-Brandstetter, Herrero, Herrero, Hilmer, Hodkinson, Hong, Ishimoto, Jing, Kahmann, Kamal Ivory, Khan, Kowdley, Larbi, Larbi, Lasheras, Le Garff-Tavernier, Lee, Lesourd, Lesourd, Ligthart, Lung, Magrone, Mariani, Mariani, Martinez-Gonzalez, Maue, McElhaney, Merchant, Meydani, Meydani, Meydani, Meydani, Mitchell, Monagas, Murasko, Mysliwska, Mònica Maijó, Nagel, Nicoletti, Nicoletti, Nikolich-Zugich, Nova, Nova, Ogawa, Ogawa, Osler, Ouwehand, Ouwehand, Pae, Paganelli, Pallast, Pawelec, Peralbo, Peralbo, Pfister, Plackett, Plowden, Prakash, Prasad, Prasad, Prasad, Prasad, Psaltopoulou, Pérez-Cabezas, Rees, Rink, Salas-Salvado, Sarah J. Clements, Saule, Saurwein-Teissl, Scarmeas, Scarmeas, Schenkein, Schiffrin, Schiffrin, Schwaiger, Shaw, Shodell, Simon R. Carding, Sofi, Sofi, Solana, Solana, Solana, Sridharan, Steger, Stout-Delgado, Swift, Tangney, Tasat, Tortorella, Tortorella, Trichopoulou, Uyemura, Valls-Pedret, van Duin, Varas, Vasto, Vasto, Vetvicka, Vulevic, Waitzberg, Wallace, Watson, Webster, Weiskopf, Weksler, Wenisch, Wikby, Willett, Wong, Wordsworth, Wu, Yaqoob, Yaqoob, Yuan, Zanni, Zissel   +217 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Innate immune response in avian macrophages elicited by Chlamydia psittaci [PDF]

, 2015
Chlamydia psittaci is a gram-negative, obligate, intracellular bacterium, which mainly infects birds and mammals. Not much is known about innate immunity initiated by C. psittaci.
Lagae, Stefanie, Vanrompay, Daisy
core  

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]

, 2018
The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda, Celias, Daiana Pamela, Cervi, Laura Alejandra, Chiapello, Laura Silvina, Motran, Claudia Cristina, Silvane, Leonardo Micael, Theumer, Martín Gustavo, Volpini, Ximena   +7 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source