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Single-cell analysis unravels the role of NK cells and monocytes in the control of SARS-CoV-2 breakthrough infections in vaccinated individuals. [PDF]

Hum Vaccin Immunother
Zheng H, Li J, Zhang X, Liao Y, Li H, Zhao X, Zhang Z, Wang J, Yu L, Li D, Zhao H, Shi H, Liu L.   +12 more
europepmc   +1 more source

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Trained immunity: adaptation within innate immune mechanisms.

Physiological Reviews, 2022
The mechanisms underlying innate immune memory have been extensively explored in the last decades but are in fact largely unknown. While the specificity of adaptive immune memory in vertebrates is ensured through the recombination of immunoglobulin ...
Jorge Domínguez-Andrés, J. C. Dos Santos, S. Bekkering, W. Mulder, J. van der Meer, N. Riksen, L. Joosten, M. Netea   +7 more
semanticscholar   +1 more source

Innate Immunity

Pediatric Clinics of North America, 2019
The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserved microbial components. This deployment generates a rapid inflammatory response, while activating the adaptive immune system.
Bani Preet, Kaur, Elizabeth, Secord
openaire   +3 more sources

Neutrophils at the crossroads of innate and adaptive immunity

Journal of Leukocyte Biology, 2020
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display an impressive array of antimicrobial functions, including ...
C. Rosales
semanticscholar   +1 more source

Adaptive innate immunity or innate adaptive immunity?

Clinical Science, 2019
AbstractThe innate immunity is frequently accepted as a first line of relatively primitive defense interfering with the pathogen invasion until the mechanisms of ‘privileged’ adaptive immunity with the production of antibodies and activation of cytotoxic lymphocytes ‘steal the show’.
Jan Černý, Ilja Stříž
openaire   +3 more sources