Results 11 to 20 of about 138,077 (236)

Mucosal dendritic cells shape mucosal immunity [PDF]

Experimental & Molecular Medicine, 2014
Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells.
Chang, Sun-Young, Ko, Hyun-Jeong, Kweon, Mi-Na   +2 more
openaire   +2 more sources

Specific Host Signatures for the Detection of Tuberculosis Infection in Children in a Low TB Incidence Country

Frontiers in Immunology, 2021
Diagnosis of tuberculosis (TB) in children remains challenging due to unspecific clinical presentation and low bacillary load. In low TB incidence countries, most cases are diagnosed by a contact screening strategy after exposure to an index TB case. Due
Alexandra Dreesman, Alexandra Dreesman, Véronique Corbière, Myriam Libin, Judith Racapé, Judith Racapé, Philippe Collart, Mahavir Singh, Camille Locht, Françoise Mascart, Violette Dirix   +10 more
doaj   +1 more source

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis

Frontiers in Immunology, 2018
The protective efficacy of human immunodeficiency virus-1 (HIV-1) antibodies (Abs) remains mostly correlated with their in vitro neutralizing activity engaging their Fab region.
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Marwa Khamassi, Marwa Khamassi, Marwa Khamassi, Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +14 more
doaj   +1 more source

Optimisation of ex vivo memory B cell expansion/differentiation for interrogation of rare peripheral memory B cell subset responses [version 2; referees: 2 approved]

Wellcome Open Research, 2018
Background: Human memory B cells play a vital role in the long-term protection of the host from pathogenic re-challenge. In recent years the importance of a number of different memory B cell subsets that can be formed in response to vaccination or ...
Luke Muir, Paul F. McKay, Velislava N. Petrova, Oleksiy V. Klymenko, Sven Kratochvil, Christopher L. Pinder, Paul Kellam, Robin J. Shattock   +7 more
doaj   +1 more source

Streptococcal Serine-Rich Repeat Proteins in Colonization and Disease

Frontiers in Microbiology, 2020
Glycosylation of proteins, previously thought to be absent in prokaryotes, is increasingly recognized as important for both bacterial colonization and pathogenesis.
Jia Mun Chan, Andrea Gori, Angela H. Nobbs, Robert S. Heyderman   +3 more
doaj   +1 more source

The Human Penis Is a Genuine Immunological Effector Site

Frontiers in Immunology, 2017
The human penis is a main portal of entry for numerous pathogens, and vaccines able to control resulting infections locally are highly desirable. However, in contrast to the gastrointestinal or vaginal mucosa, the penile immune system and mechanisms ...
Alexis Sennepin, Alexis Sennepin, Alexis Sennepin, Fernando Real, Fernando Real, Fernando Real, Marine Duvivier, Marine Duvivier, Marine Duvivier, Yonatan Ganor, Yonatan Ganor, Yonatan Ganor, Sonia Henry, Sonia Henry, Sonia Henry, Diane Damotte, Marc Revol, Sonia Cristofari, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +20 more
doaj   +1 more source

Experimental Models of Inflammatory Bowel DiseasesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2015
The understanding of the intestinal inflammation occurring in the inflammatory bowel diseases (IBD) has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation.
Patricia Kiesler, Ivan J. Fuss, Warren Strober   +2 more
doaj   +1 more source

Early diagnosis of miliary tuberculosis in a hemodialysis patient by combining two interferon-γ-release assays: a case report

BMC Nephrology, 2020
Background Patients with end-stage renal disease undergoing chronic hemodialysis (HD) are at high risk to develop tuberculosis (TB) associated with a high mortality rate.
Florence Bonkain, Dieter De Clerck, Violette Dirix, Mahavir Singh, Camille Locht, Françoise Mascart, Véronique Corbière   +6 more
doaj   +1 more source

Monoclonal antibody against EV71 3Dpol inhibits the polymerase activity of RdRp and virus replication

BMC Immunology, 2019
Background Enterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently available, novel and efficient antiviral ...
Yaoming Li, Jie Yu, Xiuwen Qi, Huimin Yan   +3 more
doaj   +1 more source

Alveolar Macrophages: Adaptation to Their Anatomic Niche during and after Inflammation

Cells, 2021
At the early stages of life development, alveoli are colonized by embryonic macrophages, which become resident alveolar macrophages (ResAM) and self-sustain by local division.
Florian Pierre Martin, Cédric Jacqueline, Jeremie Poschmann, Antoine Roquilly   +3 more
doaj   +1 more source