Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]
, 2015 BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu +3 more
core +2 more sources
Tau passive immunization inhibits not only tau but also Aβ pathology
Alzheimer's Research & Therapy, 2017 Accumulation of hyperphosphorylated tau protein is a histopathological hallmark of Alzheimer’s disease (AD) and related tauopathies. Currently, there is no effective treatment available for these progressive neurodegenerative diseases.
Chun-ling Dai +4 more
semanticscholar +1 more source
A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques [PDF]
, 2020 Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive ...
Agudelo, Marianna +25 more
core +2 more sources
Frontiers in Aging Neuroscience, 2017 Cortical and hippocampal network hyperexcitability appears to be an early event in Alzheimer’s disease (AD) pathogenesis, and may contribute to memory impairment.
S. Kazim +5 more
semanticscholar +1 more source
Care and COVID 19: Lessons for liberals and neoliberals
Child &Family Social Work, EarlyView., 2023 Abstract Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation).
Kathleen Lynch
wiley +1 more source
Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis. [PDF]
, 2002 Coliform mastitis is one of the most difficult diseases to treat in the modern dairy industry. Curative therapy with antibiotics remains only moderately effective and depends on the stage at which the disease is treated, The most successful strategies ...
Burvenich, Christian +2 more
core +3 more sources
Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]
, 2008 B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M. +9 more
core +1 more source
Archives of Virology, 2018 Passive immunity is critical for protection of neonatal piglets against porcine epidemic diarrhea virus (PEDV). Here, we investigated the immunogenicity of an orf virus (ORFV) vector expressing the full-length spike (S) protein of PEDV (ORFV-PEDV-S) in ...
Lok Raj Joshi +10 more
semanticscholar +1 more source
Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease [PDF]
, 2011 Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level
Al-Abed, Yousef +13 more
core +1 more source
Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats.
In Vivo, 2017 BACKGROUND/AIM Staphylococcus aureus infection associated with orthopedic implants cannot always be controlled. We used a knee prosthesis model with implant-related osteomyelitis in rats to explore induction of an effective immune response with active ...
N. Søe +6 more
semanticscholar +1 more source