Results 51 to 60 of about 121,206 (265)

Ecological Analysis Of Complete Basic Immunization Coverage For Infants In Indonesia (2017-2019)

Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education, 2021
Background: Complete basic immunization for infants in Indonesia is an obligation in an effort to protect infant health. It is one of the important indicators in determining the quality of health services in a certain area.
Yuli Puspita Devi, Sabarinah Prasetyo, Muthmainnah Muthmainnah   +2 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Outbreak of measles among persons with secondary vaccine failure, China, 2018

Human Vaccines & Immunotherapeutics, 2020
Although the incidence of measles has been dramatically reduced by the highly effective measles vaccine, cases of measles and outbreaks continue to occur in vaccinated population because of immunization failure.
Zhujiazi Zhang, Meng Chen, Rui Ma, Jingbin Pan, Luodan Suo, Li Lu   +5 more
doaj   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

The Relationship of Characteristics, Knowledge, Attitudes, and Mother’s Action on Immunization Compliance

Jurnal Berkala Epidemiologi, 2018
Background: Immunization coverage in Indonesia in 2015 was 86,50%, which did not meet the target of complete primary immunization was 91%. The completion of primary immunization is defined by several factors such as characteristics, knowledge, attitude ...
Alfiyan Dharma Yuda, Ira Nurmala
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Complete Childhood Immunization and Child Health Outcomes: Evidence from Indonesia

Diponegoro Journal of Economics
This study aims to examine the effect of complete childhood immunization on child health and growth outcomes in Indonesia, measured by morbidity history and Body Mass Index (BMI).
Ahmad Syahrul Fauzi, Sri Runtiningsih, Luthfi Ibnu Tsani, Karsinah Karsinah, Atik Ul Mussanadah   +4 more
doaj   +1 more source

Barriers to effective uptake and provision of immunization in a rural district in Uganda.

PLoS ONE, 2019
IntroductionHoima, one of the largest districts in mid- western Uganda, has persistently performed poorly with low immunization coverage, high immunization drop outs rates and repeated outbreaks of vaccine preventable diseases especially measles.
Oliver Ombeva Malande, Deogratias Munube, Rachel Nakatugga Afaayo, Kisakye Annet, Bongomin Bodo, Andrew Bakainaga, Elizabeth Ayebare, Sam Njunwamukama, Edison Arwanire Mworozi, Andrew Munyalo Musyoki   +9 more
doaj   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source