Results 61 to 70 of about 4,097 (210)

Complete Childhood Immunization and Child Health Outcomes: Evidence from Indonesia

Diponegoro Journal of Economics
This study aims to examine the effect of complete childhood immunization on child health and growth outcomes in Indonesia, measured by morbidity history and Body Mass Index (BMI).
Ahmad Syahrul Fauzi, Sri Runtiningsih, Luthfi Ibnu Tsani, Karsinah Karsinah, Atik Ul Mussanadah   +4 more
doaj   +1 more source

Barriers to effective uptake and provision of immunization in a rural district in Uganda.

PLoS ONE, 2019
IntroductionHoima, one of the largest districts in mid- western Uganda, has persistently performed poorly with low immunization coverage, high immunization drop outs rates and repeated outbreaks of vaccine preventable diseases especially measles.
Oliver Ombeva Malande, Deogratias Munube, Rachel Nakatugga Afaayo, Kisakye Annet, Bongomin Bodo, Andrew Bakainaga, Elizabeth Ayebare, Sam Njunwamukama, Edison Arwanire Mworozi, Andrew Munyalo Musyoki   +9 more
doaj   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells

, 2010
Rechallenge with T cell-dependent Ags induces memory B cells to re-enter germinal centers (GCs) and undergo further expansion and differentiation into plasma cells (PCs) and secondary memory B cells.
Daniela Frölich, Henrik E. Mei, Claudia Giesecke, Karin Reiter, Peter E. Lipsky, Thomas Dörner, Capucine Daridon   +6 more
core   +1 more source

Mapping geographical inequalities of incomplete immunization in Ethiopia: a spatial with multilevel analysis

Frontiers in Public Health
BackgroundImmunization is one of the most cost-effective interventions, averting 3.5–5 million deaths every year worldwide. However, incomplete immunization remains a major public health concern, particularly in Ethiopia.
Berihun Bantie, Natnael Atnafu Gebeyehu, Getachew Asmare Adella, Gizachew Ambaw Kassie, Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Mohammed Abdu Seid, Molalegn Mesele Gesese, Kirubel Dagnaw Tegegne, Melkamu Aderajew Zemene, Denekew Tenaw Anley, Anteneh Mengist Dessie, Sefineh Fenta Feleke, Tadesse Asmamaw Dejenie, Ermias Sisay Chanie, Solomon Demis Kebede, Wubet Alebachew Bayih, Natnael Moges, Yenealem Solomon Kebede   +18 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Outbreak of measles among persons with secondary vaccine failure, China, 2018

Human Vaccines & Immunotherapeutics, 2020
Although the incidence of measles has been dramatically reduced by the highly effective measles vaccine, cases of measles and outbreaks continue to occur in vaccinated population because of immunization failure.
Zhujiazi Zhang, Meng Chen, Rui Ma, Jingbin Pan, Luodan Suo, Li Lu   +5 more
doaj   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source