Results 1 to 10 of about 400,924 (337)

Surface-Enhanced Raman Scattering-Based Immunoassay Technologies for Detection of Disease Biomarkers [PDF]

Biosensors, 2017
Detection of biomarkers is of vital importance in disease detection, management, and monitoring of therapeutic efficacy. Extensive efforts have been devoted to the development of novel diagnostic methods that detect and quantify biomarkers with higher ...
Joseph Smolsky, Sukhwinder Kaur, Chihiro Hayashi, Surinder K. Batra, Alexey V. Krasnoslobodtsev   +4 more
doaj   +2 more sources

Fermentation, Purification, and Tumor Inhibition of a Disulfide-Stabilized Diabody Against Fibroblast Growth Factor-2

Frontiers in Oncology, 2021
Angiogenesis is considered one of the hallmarks of cancer and plays a critical role in the development of tumor. Fibroblast growth factor 2 (FGF-2) is a member of the FGF family and participates in excessive cancer cell proliferation and tumor ...
Simin Zhang, Jiahui Huang, Ligang Zhang, Jiangtao Gu, Qifang Song, Yaxiong Cai, Jiangchuan Zhong, Hui Zhong, Yanrui Deng, Wenhui Zhu, Jianfu Zhao, Ning Deng   +11 more
doaj   +1 more source

Preparation of DSPE-PEG-cRGD Modified Cationic Liposomes for Delivery of OC-2 shRNA and The Antitumor Effects on Breast Cancer

Pharmaceutics, 2022
Cationic liposome delivery of interfering RNA (shRNA) plays an important role in tumor therapy. The cyclic Arg-Gly-Asp (cRGD) modified cationic liposomes (cRGD-CL) were designed for targeted delivery of ONECUT2 (OC-2) shRNA (pshOC-2) to breast cancer ...
Chunyan Liu, Wenli Zhao, Ligang Zhang, Huamin Sun, Xi Chen, Ning Deng   +5 more
doaj   +1 more source

Development, Validation and Application of a Bridging ELISA for Detection of Antibodies against GQ1001 in Cynomolgus Monkey Serum

Molecules, 2023
Immunogenicity is a major issue associated with the PK, efficacy, and safety evaluation of therapeutic protein products during pre-clinical and clinical studies. A multi-tiered approach consisting of screening, confirmatory, and titration assays has been
Tingting Liu, Yajun Sun, Xiaojie Deng, Lili Shi, Wenyi Chen, Wenjing Fang, Junliang Wu, Xiaotian Fan, Xiaoqiang Chen, Jianhua Sun, Gang Qin, Likun Gong, Qiuping Qin   +12 more
doaj   +1 more source

Development of an accurate lateral flow immunoassay for PEDV detection in swine fecal samples with a filter pad design

Animal Diseases, 2021
Porcine epidemic diarrhea virus (PEDV), as the main causative pathogen of viral diarrhea in pigs, has been reported to result in high morbidity and mortality in neonatal piglets and cause significant economic losses to the swine industry. Rapid diagnosis
Siyi Zou, Lei Wu, Gan Li, Juan Wang, Dongni Cao, Tao Xu, Aiqing Jia, Yong Tang   +7 more
doaj   +1 more source

Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy

Molecular Therapy: Methods & Clinical Development, 2020
Cationic liposomes (CLs) have been regarded as the most promising gene delivery vectors for decades with the advantages of excellent biodegradability, biocompatibility, and high nucleic acid encapsulation efficiency.
Chunyan Liu, Ligang Zhang, Wenhui Zhu, Raoqing Guo, Huamin Sun, Xi Chen, Ning Deng   +6 more
doaj   +1 more source

Macrophage targeted polymeric curcumin nanoparticles limit intracellular survival of Mycobacterium tuberculosis through induction of autophagy and augment anti-TB activity of isoniazid in RAW 264.7 macrophages

Frontiers in Immunology, 2023
Rapid emergence of antibiotic resistance in tuberculosis has left us with limited resources to treat and manage multi drug resistant (MDR) cases of tuberculosis, prompting the development of novel therapeutics.
Pramod Kumar Gupta, Pramod Kumar Gupta, Priyanka Jahagirdar, Devavrat Tripathi, Padma V. Devarajan, Savita Kulkarni, Savita Kulkarni   +6 more
doaj   +1 more source

Knockout of EGFL6 by CRISPR/Cas9 Mediated Inhibition of Tumor Angiogenesis in Ovarian Cancer

Frontiers in Oncology, 2020
Tumor angiogenesis plays an important role in the progression and metastasis of ovarian cancer. EGFL6 protein is highly expressed in ovarian cancer and has been proposed to play an important role in promoting tumor angiogenesis.
Wenhui Zhu, Chunyan Liu, Tongyi Lu, Yinmei Zhang, Simin Zhang, Qi Chen, Ning Deng   +6 more
doaj   +1 more source

Development of a Point-of-Care System Based on White Light Reflectance Spectroscopy: Application in CRP Determination

Biosensors, 2021
The development of methods and miniaturized systems for fast and reliable quantitative determinations at the Point-of-Care is a top challenge and priority in diagnostics.
Dimitra Tsounidi, Georgios Koukouvinos, Vasilios Christianidis, Evangelia Legaki, Vasiliki Giogli, Konstantina Panagiotopoulou, Styliani Taka, Zoi Ekaterinidi, Sotirios Kakabakos, Ioannis Raptis, Panagiota Petrou   +10 more
doaj   +1 more source

Competitive adsorption of plasma proteins at solid—liquid interfaces [PDF]

, 1986
The competitive adsorption of human serum albumin (HSA), human immuno-γ-globulin (HIgG) and human fibrinogen (HFb) onto polystyrene (PS) at 20° C and a pH of 7.35 (phosphate-buffered saline) was studied.
Breemhaar, W., Feijen, J., Lensen, H.G.W., Smolders, C.A.   +3 more
core   +6 more sources